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Proton MR spectroscopy features of normal appearing white matter neurofibromatosis type 1

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dc.contributor.author Alkan, Alpay
dc.contributor.author Saraç, Kaya
dc.contributor.author Kutlu, Ramazan
dc.contributor.author Yakıncı, Mehmet Cengiz
dc.contributor.author Sığırcı, Ahmet
dc.contributor.author Aslan, Mehmet
dc.contributor.author Özcan, Hamdi
dc.contributor.author Yoloğlu, Saim
dc.date.accessioned 2017-06-24T06:24:08Z
dc.date.available 2017-06-24T06:24:08Z
dc.date.issued 2003
dc.identifier.citation Alkan, A. Saraç, K. Kutlu, R. Yakıncı, M. C. Sığırcı, A. Aslan, M. Özcan, H. Yoloğlu, S. (2003). Proton MR spectroscopy features of normal appearing white matter neurofibromatosis type 1. Magn Reson Imaging, (21), 1049–1053. tr_TR
dc.identifier.uri http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9D-4B963BX-M&_user=746906&_coverDate=11%2F30%2F2003&_alid=1651061172&_rdoc=7&_fmt=high&_orig=search&_origin=search&_zone=rslt_list_item&_c
dc.identifier.uri http://hdl.handle.net/11616/7169
dc.description.abstract To determine whether differences exist between neurofibromatosis type 1 (NF1) patients with or without focal lesions and healthy normal volunteers in the metabolite ratios of normal appearing white matter, 27 patients with NF1 (with parenchymal lesion, MR positive, n: 17; without parenchymal lesions, MR negative, n: 10) and 20 healthy volunteers underwent MRI and short TE (31 ms) proton MR spectroscopy (MRS). In 17 patients with parenchymal lesions, 61 focal lesions were detected by MRI. MRS was performed from normal appearing frontal and posterior parietal white matter (FWM and PWM) in NF1 and from control groups. NAA/Cr, Cho/Cr and MI/Cr ratios were calculated. Significant increase in Cho/Cr and MI/Cr ratios were found in FWM and PWM in MR negative and positive groups when compared to control group. NAA/Cr ratio in MR positive group was significantly decreased in FWM compared to control group. There were no significant differences between FWM and PWM in all metabolite ratios of MR negative group. MI/Cr ratio in MR positive group was significantly elevated in PWM compared to FWM. Metabolite changes detected by MRS could indicate demyelination and gliosis in normal appearing white matter in all NF1 patients, and additionally neuroaxonal damage in the FWM of NF1 patients with focal lesions. For that reason, in the clinical evaluation and follow-up of these patients MRS features of normal appearing white matter should be considered in addition to focal lesions. tr_TR
dc.language.iso eng tr_TR
dc.publisher Magn Reson Imaging tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Neurofibromatosis type 1 tr_TR
dc.subject Magnetic resonance spectroscopy tr_TR
dc.subject White matter tr_TR
dc.title Proton MR spectroscopy features of normal appearing white matter neurofibromatosis type 1 tr_TR
dc.type article tr_TR
dc.relation.journal Magn Reson Imaging tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.contributor.authorID 7768 tr_TR
dc.identifier.volume 21 tr_TR
dc.identifier.startpage 1049 tr_TR
dc.identifier.endpage 1053 tr_TR

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