dc.contributor.author |
Akıncı, Ayşehan |
|
dc.contributor.author |
Çetin, Dilek |
|
dc.contributor.author |
İlhan, Nevin |
|
dc.date.accessioned |
2017-07-10T12:41:53Z |
|
dc.date.available |
2017-07-10T12:41:53Z |
|
dc.date.issued |
2012 |
|
dc.identifier.citation |
AKINCI, A., ÇETİN, D., & İLHAN, N. (2012). Plasma kisspeptin levels in girls with premature thelarche. J Clin Res Pediatr Endocrinol , 4(2), 61–65. |
tr_TR |
dc.identifier.uri |
https://www.ncbi.nlm.nih.gov/pubmed/21534336 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/7366 |
|
dc.description |
J Clin Res Pediatr Endocrinol |
tr_TR |
dc.description.abstract |
Gonadotropin-releasing hormone analog (GnRHa) therapy is used in idiopathic central precocious puberty (ICPP) worldwide. It has also been shown that during this therapy, body mass index (BMI) increases slightly as a side effect. We investigated the side effects of GnRHa treatment in ICPP on body composition and insulin resistance (IR). Twenty girls (7.55 +/- 1.02 y) with ICPP were treated with GnRHa (leuprolide) for an average of 20.83 +/- 4.8 months. Bioelectrical Impedance Analysis (BIA) was used to measure the body's fat balance. Nine patients out of 20 (45%) had significant gain weight. We showed a significant elevation in trunk fat mass compare to baseline values (p < 0.01). These nine patients had high homeostasis model assessment (HOMA)-IR and low glucose/insulin (G/I) index. This study showed a slight increase in BMI, moderate increase in total body fat, and exaggerated elevation in trunk fat mass and IR in GnRHa-treated ICPP children. |
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dc.language.iso |
eng |
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dc.publisher |
J Clin Res Pediatr Endocrinol |
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dc.rights |
info:eu-repo/semantics/openAccess |
tr_TR |
dc.title |
Plasma kisspeptin levels in girls with premature thelarche |
tr_TR |
dc.type |
article |
tr_TR |
dc.relation.journal |
J Clin Res Pediatr Endocrinol |
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dc.contributor.department |
İnönü Üniversitesi |
tr_TR |
dc.contributor.authorID |
10983 |
tr_TR |
dc.contributor.authorID |
132799 |
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dc.contributor.authorID |
7573 |
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dc.identifier.volume |
4 |
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dc.identifier.issue |
2 |
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dc.identifier.startpage |
61 |
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dc.identifier.endpage |
65 |
tr_TR |