Özet:
Objective: The aim of this study was to investigate whether insulin deficiency and increased
catabolism may have a role in the regulation of plasma glucagon-like peptide (GLP)-1 and GLP-
2 levels in children with diabetic ketoacidosis (DKA) and whether insulin treatment may affect
the levels of these polypeptides.
Methods: Plasma GLP-1 and -2 levels were measured in 24 patients with DKA aged 8 to 14
years before insulin infusion (time 0), when ketonemia and acidosis disappeared (time 1), and
when weight gain started (time 2). Eighteen healthy children aged 8 to 14 years constituted the
control group.
Results: At time 0, mean plasma GLP-1 and GLP-2 levels were significantly elevated in the patients
compared with the control group (p<0.05 and p<0.01, respectively). At time 1 when ketonemia and
acidosis disappeared, GLP-1 and GLP-2 levels decreased significantly from the initial levels (p<0.05
and p<0.01, respectively). At this time, while GLP-1 level was not different from that of the controls,
GLP-2 level was higher than that of the controls (p<0.05). GLP-1 and-2 levels did not show any significant
differences between the patients and controls when weight gain started (time 2).
Conclusion: Our results show that DKA is associated with increased plasma GLP-1 and -2 concentrations.
Effective fluid and insulin treatment resulted in a significant decrease in plasma GLP-
1 and -2 levels. This may be due to the negative feedback effect of insulin on the production of
these polypeptides.
