Özet:
The purpose of the present
study was to identify the role of abnormalities in
DNA repair pathways by measuring the XPD and
XRCC1 gene polymorphisms.
MATERIALS AND METHODS: Thirty-five patients
with abnormal cervical cytology (study
group) and 10 women with normal cytology
(control group) were included in the study. The
polymorphisms of XRCC1 Arg194Trp, XRCC1
Arg399Gln and XPD Lys751Gln genes were investigated
from the blood samples.
RESULTS: There was no statistically significant
difference in allele frequencies of XPD gene
among the groups (p = 0.097), while XRCC1R399Q
gene polymorphism was strikingly more frequent
in the study group than that of control cases (p =
0.029). The prevalence of XRCC1R194W gene polymorphism
on the other hand, was similar between
the groups (p = 0.579).
CONCLUSIONS: Patients with abnormal and
normal cervical cytology have similar XPD gene
polymorphism. However, the frequency of gene
polymorphism in XRCC1 Arg 399 Gln codon was
significantly higher in abnormal cervical cytology
group.
