Özet:
Tumor necrosis factor (TNF)-a antibodies have been shown to reduce liver damage in different models. We
investigated the effects of infliximab (a TNF-a antibody) on liver damage in thioacetamide (TAA)-induced hepatotoxicity
in rats. Group 1 (n ¼ 8) was the control group. In group 2 (n ¼ 8), the TAA group, the rats received
300 mg/kg intraperitoneal (ip) TAA daily for 2 days. In group 3 (n ¼ 8), the TAA þ Infliximab (INF) group,
infliximab (5 mg/kg ip daily) was administered 48 hours before the first dose of TAA daily for 2 days and
was maintained for 4 consecutive days. In group 4 (n ¼ 8), the INF group, the rats received only ip infliximab
(5 mg/kg) daily. Livers were excised for histopathological and biochemical tests (thiobarbituric-acid-reactive
substances [TBARS], and myeloperoxidase [MPO]). Serum ammonia, aspartate transaminase (AST), alanine
transaminase (ALT), TNF-a, liver TBARS and MPO levels, and liver necrosis and inflammation scores in the
TAA group were significantly higher than in the control and INF groups (all p < 0.01). All parameters except
AST were not significantly different between TAA and TAA þ INF. In conclusion, our results suggest that oxidative
stress plays an important role in TAA-induced hepatotoxicity, and infliximab does not improve oxidative
liver damage.
