Özet:
Expression levels of various intestinal proteins involved in postprandial
lipoprotein assembly as well as plasma triglyceride concentration
exhibit daily oscillations indicating circadian control. The length of the
carbon chain and degree and position of unsaturation of fatty acids
influence triglyceride secretion by the enterocytes. To this end, effects
of reciprocal interactions of various single fats/oil (olive oil, fish oil or
butter) gavaging either in active or passive phase were investigated in
rats. Fat/oil gavaged in the active phase of circadian rhythm resulted
in higher postprandial serum triglyceride levels compared to that
in the passive phase. Moreover, olive oil led to higher MTP activity
and apo B-48 gene expression, while fish oil gavaging caused more
prominent apo B-48 and MTP gene expression when they were given
in the passive phase. The present results indicate that circadian time at
which fat or oil gavaged once might exert influence on postprandial
lipoprotein synthesis/assembly.
