dc.contributor.author |
Kayhan, Başak |
|
dc.contributor.author |
Kayhan, Burçak |
|
dc.contributor.author |
Akdoğan, Meral |
|
dc.date.accessioned |
2017-08-03T12:58:57Z |
|
dc.date.available |
2017-08-03T12:58:57Z |
|
dc.date.issued |
2004 |
|
dc.identifier.citation |
Kayhan, B. Kayhan, B. Akdoğan, M. (2004). Can IL 2R alpha be a valuable marker along with CA 19 9 in the diagnosis of chronic pancreatitis and pancreatic cancer. International journal of biological markers. 19(3):196-202. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/11616/7443 |
|
dc.description.abstract |
Pancreatic cancer is characterized initially by non-specific abdominal symptoms followed by rapid tumor progression. Although chronic pancreatitis is a benign disorder, it can be one of the causative factors of pancreatic cancer. The level of the tumor marker carbohydrate antigen 19-9 (CA 19-9) in pancreatic cancer does not correlate with the stage of the neoplasm. Soluble interleukin 2 receptor (sIL-2R) is a cytokine that shows increased levels during some inflammatory processes and malignant disorders.
AIM:
Our aim in this study was to investigate whether sIL-2Ralpha levels can be used in association with CA 19-9 in the early diagnosis of pancreatic cancer and chronic pancreatitis.
PATIENTS:
Serum samples were obtained from the blood of 21 pancreatic cancer patients without distant metastasis who were deemed inoperable, 16 chronic pancreatitis patients and 20 normal volunteers.
RESULTS:
We did not find any significant differences in CA 19-9 levels between normal controls and patients with chronic pancreatitis. There was a significant difference in the levels between the control group and the pancreatic cancer group (p = 0.003) and between patients with chronic pancreatitis and those with pancreatic cancer (p = 0.004). Although there was no significant difference in sIL-2Ralpha levels between the control group and the patient groups, we found a slight correlation between sIL-2Ralpha and CA 19-9 levels in the pancreatic cancer group (p = 0.003, r = 0.623) and a more marked correlation in the chronic pancreatitis group (p < 0.01, r = 0.751).
CONCLUSION:
According to our results, sIL-2Ralpha alone is not a good candidate marker in the diagnosis of pancreatic cancer; it can, however, be used in association with CA 19-9 for this purpose. |
tr_TR |
dc.language.iso |
eng |
tr_TR |
dc.publisher |
International journal of biological markers |
tr_TR |
dc.rights |
info:eu-repo/semantics/embargoedAccess |
tr_TR |
dc.title |
Can IL 2R alpha be a valuable marker along with CA 19 9 in the diagnosis of chronic pancreatitis and pancreatic cancer |
tr_TR |
dc.type |
article |
tr_TR |
dc.relation.journal |
International journal of biological markers |
tr_TR |
dc.contributor.department |
İnönü Üniversitesi |
tr_TR |
dc.contributor.authorID |
41809 |
tr_TR |
dc.identifier.volume |
19 |
tr_TR |
dc.identifier.issue |
3 |
tr_TR |
dc.identifier.startpage |
196 |
tr_TR |
dc.identifier.endpage |
202 |
tr_TR |