DSpace Repository

Comparative effectiveness of several agents for preventing postoperative adhesions

Show simple item record

dc.contributor.author Kutlay, Jehat
dc.contributor.author Özer, Yusuf
dc.contributor.author Işık, Burak
dc.contributor.author Kargıcı, Hülagü
dc.date.accessioned 2017-08-10T10:21:10Z
dc.date.available 2017-08-10T10:21:10Z
dc.date.issued 2004
dc.identifier.citation Kutlay, J. Özer, Y. Işık, B. Kargıcı, H. (2004). Comparative effectiveness of several agents for preventing postoperative adhesions. World Journal of Surgery. 28, 662–665. tr_TR
dc.identifier.issn 0364-2313
dc.identifier.uri http://link.springer.com/10.1007/s00268-004-6825-6
dc.identifier.uri http://hdl.handle.net/11616/7532
dc.description.abstract Abstract. Postoperative adhesions (PAs) are usually clinically asymptomatic. Symptomatic cases, however, may present with chronic abdominal and pelvic pain, infertility, and intestinal obstruction; and they may require intensive, costly therapeutic modalities. Various agents have been used to prevent PAs, but the results indicate general suboptimal effectiveness. Our objective was to evaluate the comparative effectiveness of two pharmacologic agents for preventing PA: nadroparine calcium (lowmolecular-weight heparin, or LMWH) and aprotinin, as well as a barrier agent, sodium hyaluronate/carboxymethycellulose (SCMC). Our subjects were 40 male Wistar-Albino rats divided into four groups, each consisting of 10 rats, which underwent standard cecal abrasion preceding midline laparotomy. In the control group (group 1) 1 ml of 0.9% NaCl was administered intraperitoneally before abdominal closure. In the three preventive groups, 100 U AXa (anti factor X activity) LMWH, 1800 IU aprotinin, and SCMC were administered intraperitoneally to groups 2, 3, and 4, respectively. Relaparotomy was performed on the 14th postoperative day. Visceral and abdominal wall adhesions were scored in a blinded fashion. The adhesion scores (mean ± SD) for groups 1, 2, 3, and 4 were 2.00 ± 0.67, 0.6.00 ± 0.84, 1.10 ± 0.74, and 0.20 ± 0.42, respectively. The differences in the adhesion scores among all three preventive groups (groups 2, 3, 4) were statistically significant when compared with the control group (p < 0.001, p = 0.017, p < 0.001, respectively). Intraperitoneal SCMC and administration of LMWH were more effective than giving aprotinin. tr_TR
dc.language.iso eng tr_TR
dc.publisher World Journal of Surgery tr_TR
dc.relation.isversionof 10.1007/s00268-004-6825-6 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.title Comparative effectiveness of several agents for preventing postoperative adhesions tr_TR
dc.type article tr_TR
dc.relation.journal World Journal of Surgery tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.contributor.authorID 110105 tr_TR
dc.identifier.volume 28 tr_TR
dc.identifier.startpage 662 tr_TR
dc.identifier.endpage 665 tr_TR

Files in this item

This item appears in the following Collection(s)

Show simple item record