Abstract:
Background The aim of this study was to evaluate the
macular thickness (MT), ganglion cell complex (GCC),
and circum-papillary retinal nerve fiber layer (RNFL) thickness
in primary open-angle glaucoma (POAG) and normal
tension glaucoma (NTG) with spectral domain optical coherence
tomography (SD-OCT).
Methods A total of 169 subjects were enrolled: 52 normal
subjects, 61 with POAG, and 56 with NTG. Spectraldomain
optical coherence tomography (SD-OCT) was used
to analyze MT, GCC, and RNFL thickness. To compare the
discrimination capabilities between the MT, GCC, and
RNFL thickness measurements, we analyzed the areas under
the receiver operating characteristic (ROC) curves (AUCs).
The relationships between GCC and RNFL measurement
and also the relationships of the groups, with age, gender,
GCC, and RNFL thickness were assessed.
Results Normal subjects showed the thickest superior
and inferior GCC, followed by in order NTG and
POAG (p<0.05). While there was a statistically difference
in MT value of the normal subjects and the glaucoma
patients (p<0.05), MT value did not differ between POAG and NTG (p<0.05). RNFL thickness
parameters were significantly greater in normal subjects,
followed in order by the NTG, and POAG (p<0.05).
Between the normal and entire glaucoma groups, all
GCC and RNFL parameters showed the similar discrimination
power. RNFL thickness parameters correlated
significantly with all GCC thickness (p<0.05). Superior
RNFL thickness was the only independent variable between
the POAG and NTG patients (odds ratio (OR)
0.942, p00.004, 95 %CI 0.905–0.981).
Conclusions SD-OCT evaluation results suggest higher
GCC and RNFL parameters for NTG than POAG.
