Effects of montelukast on burn wound healing in a rat model

Abstract

Purpose: Montelukast, a selective cysteinyl leukotriene D4-receptor antagonist, is used in the treatment of asthma. In a rat model, our aim was to investigate the e!ects of montelukast, alone or in combination with topical antibiotics, on local burn wound healing. Methods: Rats were randomly allocated to four groups a"er local burn development: Group 1; rats were le" to secondary healing without treatment, Group 2; a dose of 10 mg/ kg montelukast was given by gastric gavage once a day for 10 days, Group 3; rats were treated with topical pomade (bacitracin neomycin sulphate), and Group 4; rats were treat with a combination of topical antibiotic and montelukast (10 mg/kg were given by gastric gavage once a day for 10 days). Skin biopsies were taken on days 3, 10, 14, and 20 relative to burn induction. Results: Reepithelialization in the pomade and montelukast+pomade groups on the 10th day was signi$cantly greater, in comparison with control and montelukast groups (p<0.05). For the montelukast group, edema (on the 14th day) and angiogenesis, $broblast proliferation, edema and macrophage in$ltration (on the 20th day) were statistically improved in comparison with the control group (p<0.05). For the montelukast+pomade group, angiogenesis, $broblast proliferation and macrophage in$ltration (on the 10th day), and angiogenesis, $broblast proliferation, edema and macrophage in$ltration (on the 14th and 20th days) were statistically improved in comparison with the control group (p<0.05). Conclusion: In conclusion, montelukast was e!ective on burn wound healing. Moreover, the e!ect was ampli$ed when combined with topical antibiotics applied in the early stage of burn wound healing.