dc.contributor.author |
Yilmaz, E |
|
dc.contributor.author |
Gul, M |
|
dc.contributor.author |
Melekoglu, R |
|
dc.contributor.author |
Coskun, EI |
|
dc.contributor.author |
Sahin, N |
|
dc.contributor.author |
Gul, S |
|
dc.contributor.author |
Bastemur, AG |
|
dc.contributor.author |
Ciplak, B |
|
dc.date.accessioned |
2022-10-11T13:42:20Z |
|
dc.date.available |
2022-10-11T13:42:20Z |
|
dc.date.issued |
2018 |
|
dc.identifier.uri |
http://hdl.handle.net/11616/76917 |
|
dc.description.abstract |
Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer. |
|
dc.description.abstract |
Methods The study participants were divided into patients with benign endometrial pathologies (Group 1, n=23), patients with endometrial hyperplasia (Group 2, n=21) and patients with endometrial cancer (Group 3, n=20). NEDD4L expression was detected by immunohistochemical staining and H scores were calculated to standardize staining intensity. Statistical analysis was performed using SPSS 16.0. |
|
dc.description.abstract |
Results NEDD4L expression levels according to H scores were significantly lower in patients diagnosed with endometrial cancer compared with those with benign endometrial pathologies. |
|
dc.description.abstract |
Conclusion NEDD4L is involved in maintaining cell stability, and reduced NEDD4L expression as a result of gene mutation may disrupt this balance in favor of tumorigenesis. |
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dc.description.abstract |
C1 [Yilmaz, Ercan; Melekoglu, Rauf; Coskun, Ebru Inci; Bastemur, Ayse Gulcin] Inonu Univ, Med Fac, Obstet & Gynecol Dept, TR-44000 Malatya, Turkey. |
|
dc.description.abstract |
[Gul, Mehmet; Gul, Semir] Inonu Univ, Med Fac, Histol & Embryol Dept, Malatya, Turkey. |
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dc.description.abstract |
[Sahin, Nurhan] Bezmialem Fdn Univ, Istanbul Fac, Pathol Dept, Istanbul, Turkey. |
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dc.description.abstract |
[Ciplak, Baris] Beydagi State Hosp, Malatya, Turkey. |
|
dc.source |
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH |
|
dc.title |
Neural precursor cell-expressed developmentally down-regulated 4-like: a |
|
dc.title |
new biomarker in the pathophysiology of endometrial cancer |
|