Özet:
Although the anthracyclines have gained widespread use in the treatment of childhood hematological
malignancies and solid tumors, cardiotoxicity is the major limiting factor in the use of anthracyclines.
The aim of this study was to assess the mitral annular displacement by tissue tracking in pediatric
malignancy survivors who had been treated with anthracycline groups chemotheraphy and compare
with the tissue Doppler and conventional two dimensional measurements and Doppler indices. In this
study, 32 pediatric malignancy survivors and 22 healthy children were assessed with 2D, colour-coded
echocardiography. Left ventricular ejection fraction, fractional shortening, stroke volume, cardiac
output, cardiac index and diastolic functions were measured. All subjects were assessed with tissue
Doppler echocardiography, mitral annular displacements, and also with tissue tracking method. We
detected that peak velocity of the early rapid filling on tissue Doppler (E
) was lower (p < 0.05) and
the ratio of early peak velocity of rapid filling on pulse Doppler to tissue Doppler (E/E
) values were
statistically higher in patient group than control group (p < 0.05). Myocardial performance index
values were also higher in patient group than the control group (p < 0.01). It appears that MPI is
a useful echocardiograghic method than tissue tracking of mitral annular displacement in patients
with pediatric cancer survivors who had subclinical diastolic dysfunction.
