dc.contributor.author |
Ara, Cengiz |
|
dc.contributor.author |
Bay Karabulut, Aysun |
|
dc.date.accessioned |
2017-09-07T10:37:28Z |
|
dc.date.available |
2017-09-07T10:37:28Z |
|
dc.date.issued |
2009 |
|
dc.identifier.citation |
Ara, C. Bay Karabulut, A. (2009). Melatonin ameliorates tacrolimus FK 506 s induced immunosupressive effect in rat liver. 41, 1875–1877. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/11616/7728 |
|
dc.description.abstract |
Tacrolimus (FK-506) is a powerful immunosuppressive agent that modulates neutrophil
infiltration during inflammation. In this study, we sought to investigate the effects of
melatonin on malondialdehyde (MDA), nitric oxide (NO), interleukin (IL)-6, and tumor
necrosis factor-alpha (TNF-alpha) to oppose the negative effects of the immunosupressant
FK-506. Group A was sham; group B, tacrolimus (1 mg/kg/d subcutaneously); and Group C
received tacrolimus (1 mg/kg/d plus melatonin). All tissues underwent histopathologic
examination. The MDA level in group B increased 53% compared with the sham group (P
.001); in group C, the MDA level decreased 16% compared with group B (P .05). While
TNF-alpha in group B increased 68.8% compared with the sham group (P .001) and in
group C it decreased 63.5% compared with the sham group. The IL-6 level in group B
increased 81%; in group C, it decreased 13% compared with group B. NO levels in group
B increased 48% compared with the sham group and increased by 15% in group B
compared with group C. Thus melatonin may serve as a protective agent against the side
effects of tacrolimus. |
tr_TR |
dc.language.iso |
eng |
tr_TR |
dc.publisher |
Transplant Proc |
tr_TR |
dc.relation.isversionof |
10.1016/j.transproceed.2008.12.035 |
tr_TR |
dc.rights |
info:eu-repo/semantics/openAccess |
tr_TR |
dc.title |
Melatonin ameliorates tacrolimus FK 506 s induced immunosupressive effect in rat liver |
tr_TR |
dc.type |
article |
tr_TR |
dc.relation.journal |
Transplant Proc |
tr_TR |
dc.contributor.department |
İnönü Üniversitesi |
tr_TR |
dc.contributor.authorID |
109416 |
tr_TR |
dc.identifier.volume |
41 |
tr_TR |
dc.identifier.startpage |
1875 |
tr_TR |
dc.identifier.endpage |
1877 |
tr_TR |