dc.contributor.author |
Çenesiz, Sena |
|
dc.contributor.author |
Yarım, G. F. |
|
dc.contributor.author |
Bay Karabulut, Aysun |
|
dc.contributor.author |
Ara, Cengiz |
|
dc.date.accessioned |
2017-09-08T08:05:37Z |
|
dc.date.available |
2017-09-08T08:05:37Z |
|
dc.date.issued |
2007 |
|
dc.identifier.citation |
Çenesiz, S. Yarım, G. F. Bay Karabulut, A. Ara, C. (2007). Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol. Dtsch Tierarztl Wochenschr. 114(9):345-348. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/11616/7733 |
|
dc.description.abstract |
The aim of this study was to evaluate the role of antioxidant enzyme activity and nitric oxide levels induced by 28 day biliary obstruction in the rat. A total of 21 young Swiss albino rats were divided in to 3 groups. Bile duct ligations, bile duct ligations plus resveratrol, sham operated. Bile duct ligations plus resveratrol group received 10 mg/kg dose of resveratrol intraperitonealy once daily throughout for 28 days. Liver damage and cholestasis were determined by biochemical examination. SOD, CAT and GSH-PX activity decreased in BDL group compared with shame opareted groups (p < 0.001). NO levels increased in BDL groups compared with shame opareted groups (p < 0.001). SOD, CAT and GSH-PX activity was found higher in BDL+resveratrol treated groups than BDL groups (p < 0.001). In addition this NO levels decreased in BDL+resveratrol treated groups than BDL groups (p < 0.001). In conclusion, it is thought that resveratrol may be used as a protective agent in biliary obstructions; however, further clinical and experimental studies are needed to verify its antioxidative and hepatoprotective effects. |
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dc.language.iso |
eng |
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dc.publisher |
Dtsch Tierarztl Wochenschr |
tr_TR |
dc.rights |
info:eu-repo/semantics/embargoedAccess |
tr_TR |
dc.title |
Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol |
tr_TR |
dc.type |
article |
tr_TR |
dc.relation.journal |
Dtsch Tierarztl Wochenschr |
tr_TR |
dc.contributor.department |
İnönü Üniversitesi |
tr_TR |
dc.contributor.authorID |
109416 |
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dc.identifier.volume |
114 |
tr_TR |
dc.identifier.issue |
9 |
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dc.identifier.startpage |
345 |
tr_TR |
dc.identifier.endpage |
348 |
tr_TR |