Effects of thymoquinone and curcumin on the regeneration of rat livers

Abstract

Purpose: To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver.

Methods: Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathological specimens were studied using the Ki-67 Proliferation Index(PI); and arginase(Arg), tissue plasminogen activator(tPA), ceruloplasmin(Cer) and nitric oxide(NO) were studied in biochemical analysis.

Results: Our results showed that Ki-67 proliferation index was low in Groups 1. The proliferation coefficient was significantly higher in the Group 2 and Group 4 than in the Group 1 and Group 3.(P < 0.001 between Groups 1 and 2, 1 and 4, and 3 and 4). There was no difference between Groups 2 and 4 (P = 1). The results of the biochemical Arg, tPA and Cer test showed statistically between the Group 1 and Group 2. NO showed significant differences Group 1 and 3.

Conclusions: Thymoquinone and curcumin both have known positive effects on the organism. Histological and biochemical tests showed that thymoquinone is more effective than curcumin.

C1 [Gozeneli, Orhan; Tatli, Faik; Bardakci, Osman] Harran Univ, Fac Med, Dept Gen Surg, Sanliurfa, Turkey.

[Gunes, Ali Erdal] Harran Univ, Fac Med, Dept Hyperbar & Underwater Med, Sanliurfa, Turkey.

[Guldur, Muhammed Emin] Harran Univ, Fac Med, Dept Med Pathol, Sanliurfa, Turkey.

[Taskin, Abdullah] Harran Univ, Fac Med, Dept Med Biochem, Sanliurfa, Turkey.

[Yilmaz, Mehmet] Inonu Univ, Fac Med, Dept Liver Transplantat, Malatya, Turkey.