dc.contributor.author |
Yilmaz, E |
|
dc.contributor.author |
Coskun, EI |
|
dc.contributor.author |
Gul, M |
|
dc.contributor.author |
Sahin, N |
|
dc.contributor.author |
Tuncay, G |
|
dc.contributor.author |
Simsek, Y |
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dc.date.accessioned |
2022-10-13T10:44:56Z |
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dc.date.available |
2022-10-13T10:44:56Z |
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dc.date.issued |
2017 |
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dc.identifier.uri |
http://hdl.handle.net/11616/77775 |
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dc.description.abstract |
Objective: Examination of the role of nuclear factor-kappa beta (NF-kappa B) expression in the etiopathogenesis of endometrial cancer, by means of the immunohistochemical method. Materials and Methods: Patients who applied to participate in the study at the clinic were grouped into three categories: those diagnosed with benign endometrial pathology, those with endometrial hyperplasia, and those with endometrial cancer. NF-kappa B analysis was conducted in the endometrial tissues of the patients' paraffin blocks by means of the immunohistochemical method. For objective assessment purposes, the H score of each patient was calculated. SP SS 15.0 program was employed for statistical analysis. Results: The average H score of the first group, comprising benign endometrial pathologies, was 102.4 +/- 85.9, that of the hyperplasia group was 143.6 +/- 122.4, and that of the cancer group was 276.8 +/- 61.8. The average values of groups 1 and 2 were similar (p = 0.349); however, the third group's average H score was significantly higher (p < 0.001). Conclusion: NF-kappa B, which is a critical mediator in the inflammation process, might be related to the development of premalign and malign endometrial changes. |
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dc.description.abstract |
C1 [Yilmaz, E.; Coskun, E. I.; Tuncay, G.] Inonu Univ, Sch Med, Dept Obstet & Gynecol, Malatya, Turkey. |
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dc.description.abstract |
[Gul, M.] Inonu Univ, Sch Med, Dept Histol & Embryol, Malatya, Turkey. |
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dc.description.abstract |
[Sahin, N.] Inonu Univ, Sch Med, Dept Pathol, Malatya, Turkey. |
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dc.description.abstract |
[Simsek, Y.] Private Clin, Kirikkale, Turkey. |
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dc.source |
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY |
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dc.title |
Nuclear factor-kappa beta pathway and endometrial cancer: a pilot study |
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