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Living donor liver transplantation for hepatocellular carcinoma

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dc.contributor.author Işık, Burak
dc.contributor.author İnce, Volkan
dc.contributor.author Karakaya, Hüseyin Çağlar
dc.contributor.author Kayaalp, Cüneyt
dc.contributor.author Yılmaz, Sezai
dc.date.accessioned 2017-11-30T07:05:19Z
dc.date.available 2017-11-30T07:05:19Z
dc.date.issued 2012
dc.identifier.citation B. Isik, V. Ince, K. Karabulut, C. Kayaalp, and S. Yilmaz (2012). Living donor liver transplantation for hepatocellular carcinoma. Transplantation Proceedings. tr_TR
dc.identifier.uri http://hdl.handle.net/11616/7848
dc.description Transplantation Proceedings, 44, 1713–1716 (2012) tr_TR
dc.description.abstract Background. Liver transplantation is a widely accepted modality in the treatment of hepatocellular carcinoma (HCC). In our center, patients with HCC limited to the liver without macrovascular invasion are accepted as candidates for living donor liver transplantation (LDLT). The aim of this study was to describe the patient characteristics and outcomes at a single institution to analyze the impact of our criteria on the survival of HCC patients. Patients and Methods. We reviewed the medical records of all HCC (n 105) patients who underwent liver transplantation in our institution. We excluded deaths in the early postoperative period and deceased donor liver transplantation (DDLT) patients, leaving 74 subjects (65 males and 9 female). Their median age was 53 years (range, 19–69). Univariate Kaplan-Meier and multivariate Cox proportional hazards models were used to analyze overall and disease-free survivals. Results. Thirty-two (43%) patients were within the Milan criteria, and 42 (57%) exceeded them. One- and 2-year overall survival rates for patients within versus exceeding the Milan criteria were 72% versus 68% and 61% versus 58%, respectively. One- and 2-year disease-free survival rates for patients within versus exceeding the Milan criteria were 72% versus 68% and 60% versus 55%, respectively (P .05). Tumor recurrence rates for patients within versus exceeding the Milan criteria were 0% versus 36%, respectively (P .0002). Alpha-fetoprotein level was the only predictor of overall survival; alphafetoprotein level and tumor differentiation were predictors of disease-free survival. Conclusion. Although higher recurrence rates have been observed among patients exceeding the Milan criteria, LDLT is the only treatment option for the patients in countries with limited sources of cadaveric organs. As a general principle, we believe that the use of cadaveric donor liver grafts is not suitable for patients who exceed these criteria. tr_TR
dc.language.iso eng tr_TR
dc.publisher Transplantation Proceedings tr_TR
dc.relation.isversionof 10.1016/j.transproceed.2012.05.033 tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.title Living donor liver transplantation for hepatocellular carcinoma tr_TR
dc.type article tr_TR
dc.relation.journal Transplantation Proceedings tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.contributor.authorID 110105 tr_TR
dc.contributor.authorID 28465 tr_TR
dc.contributor.authorID 109262 tr_TR
dc.contributor.authorID 112689 tr_TR
dc.identifier.volume 0 tr_TR
dc.identifier.issue 0 tr_TR
dc.identifier.startpage 0 tr_TR
dc.identifier.endpage 0 tr_TR

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