| dc.contributor.author |
Ozen, F |
|
| dc.contributor.author |
Tekin, S |
|
| dc.contributor.author |
Koran, K |
|
| dc.contributor.author |
Sandal, S |
|
| dc.contributor.author |
Gorgulu, AO |
|
| dc.date.accessioned |
2022-10-13T11:03:47Z |
|
| dc.date.available |
2022-10-13T11:03:47Z |
|
| dc.date.issued |
2016 |
|
| dc.identifier.uri |
http://hdl.handle.net/11616/78494 |
|
| dc.description.abstract |
A series of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitrile (2-9) were designed and synthesized to develop new cancer drugs. The structures of synthesized compounds 2-9 were described by using melting point, mass (MALDI-TOF-MS), FT-IR, elemental analysis, H-1, C-13, C-13-APT and 2D NMR spectroscopy. The in vitro anticancer activities of 2-9 against human breast cancer (MCF-7), human prostate cancer (PC-3) and human ovarian cancer cells (A2780) were investigated by [3-(4,5-dimethylthiazol)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide] (MTT) assay method. Additionally, the LogIC(50) values of these compounds on A2780, MCF-7 and PC-3 cell lines were calculated by using inhibition % values by the GraphPad Prism 6 program on a computer. The results indicated that these compounds have high anticancer activity against MCF-7, PC-3 and A2780 cell lines (especially A2780 cell lines, p < 0.05). |
|
| dc.description.abstract |
C1 [Ozen, Furkan; Koran, Kenan; Gorgulu, Ahmet Orhan] Firat Univ, Dept Chem, Fac Sci, TR-23119 Elazig, Turkey. |
|
| dc.description.abstract |
[Tekin, Suat; Sandal, Suleyman] Inonu Univ, Dept Physiol, Fac Med, TR-44280 Malatya, Turkey. |
|
| dc.source |
RESEARCH ON CHEMICAL INTERMEDIATES |
|
| dc.title |
Synthesis of |
|
| dc.title |
2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitriles: in |
|
| dc.title |
vitro anticancer activity against MCF-7, PC-3 and A2780 cancer cell |
|
| dc.title |
lines |
|