Aim: To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. Patients & methods: The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. Results: The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p <= 0.001, p = 0.001 and p = 0.012, respectively). Conclusion: Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.
C1 [Yazici, Ozan; Aksoy, Sercan; Zengin, Nurullah] Ankara Numune Training & Res Hosp, Dept Med Oncol, TR-06410 Ankara, Turkey.
[Ozdemir, Nuriye; Sendur, Nahit] Yildirim Beyazit Univ, Fac Med, Dept Med Oncol, TR-06800 Ankara, Turkey.
[Duran, Ayse Ocak; Karaca, Halit; Ozkan, Metin] Erciyes Univ, Fac Med, Dept Med Oncol, TR-38030 Kayseri, Talas Melikgazi, Turkey.
[Menekse, Serkan; Goksel, Gamze] Celal Bayar Univ, Fac Med, Dept Med Oncol, TR-45030 Uncubozkoy, Manisa, Turkey.
[Arpaci, Erkan] Sakarya Univ, Educ & Res Hosp, Dept Med Oncol, TR-54100 Sirinevler, Sakarya, Turkey.
[Hacibekiroglu, Ilhan] Trakya Univ, Fac Med, Dept Med Oncol, TR-22050 Karaagac, Edirne, Turkey.
[Bilgetekin, Irem; Buyukberber, Suleyman] Gazi Univ, Fac Med, Dept Med Oncol, TR-06560 Emniyet, Ankara, Turkey.
[Kacan, Turgut] Cumhuriyet Univ, Fac Med, Dept Med Oncol, TR-58140 Sivas, Imaret, Turkey.
[Aksoy, Sercan; Elkiran, Emin Tamer] Inonu Univ, Fac Med, Dept Med Oncol, TR-44000 Malatya, Centre, Turkey.
[Cokmert, Suna] Izmir Kent Hosp, Dept Med Oncol, Izmir, Turkey.
[Uysal, Mukremin] Afyon Kocatepe Univ, Fac Med, Afyon, Turkey.