| dc.contributor.author |
Erdem, H |
|
| dc.contributor.author |
Ozturk-Engin, D |
|
| dc.contributor.author |
Elaldi, N |
|
| dc.contributor.author |
Gulsun, S |
|
| dc.contributor.author |
Sengoz, G |
|
| dc.contributor.author |
Crisan, A |
|
| dc.contributor.author |
Johansen, IS |
|
| dc.contributor.author |
Inan, A |
|
| dc.contributor.author |
Nechifor, M |
|
| dc.contributor.author |
Al-Mahdawi, A |
|
| dc.contributor.author |
Civljak, R |
|
| dc.contributor.author |
Ozguler, M |
|
| dc.contributor.author |
Savic, B |
|
| dc.contributor.author |
Ceran, N |
|
| dc.contributor.author |
Cacopardo, B |
|
| dc.contributor.author |
Inal, AS |
|
| dc.contributor.author |
Namiduru, M |
|
| dc.contributor.author |
Dayan, S |
|
| dc.contributor.author |
Kayabas, U |
|
| dc.contributor.author |
Parlak, E |
|
| dc.contributor.author |
Khalifa, A |
|
| dc.contributor.author |
Kursun, E |
|
| dc.contributor.author |
Sipahi, OR |
|
| dc.contributor.author |
Yemisen, M |
|
| dc.contributor.author |
Akbulut, A |
|
| dc.contributor.author |
Bitirgen, M |
|
| dc.contributor.author |
Dulovic, O |
|
| dc.contributor.author |
Kandemir, B |
|
| dc.contributor.author |
Luca, C |
|
| dc.contributor.author |
Parlak, M |
|
| dc.contributor.author |
Stahl, JP |
|
| dc.contributor.author |
Pehlivanoglu, F |
|
| dc.contributor.author |
Simeon, S |
|
| dc.contributor.author |
Ulu-Kilic, A |
|
| dc.contributor.author |
Yasar, K |
|
| dc.contributor.author |
Yilmaz, G |
|
| dc.contributor.author |
Yilmaz, E |
|
| dc.contributor.author |
Beovic, B |
|
| dc.contributor.author |
Catroux, M |
|
| dc.contributor.author |
Lakatos, B |
|
| dc.contributor.author |
Sunbul, M |
|
| dc.contributor.author |
Oncul, O |
|
| dc.contributor.author |
Alabay, S |
|
| dc.contributor.author |
Sahin-Horasan, E |
|
| dc.contributor.author |
Kose, S |
|
| dc.contributor.author |
Shehata, G |
|
| dc.contributor.author |
Andre, K |
|
| dc.contributor.author |
Alp, A |
|
| dc.contributor.author |
Cosic, G |
|
| dc.contributor.author |
Gul, HC |
|
| dc.contributor.author |
Karakas, A |
|
| dc.contributor.author |
Chadapaud, S |
|
| dc.contributor.author |
Hansmann, Y |
|
| dc.contributor.author |
Harxhi, A |
|
| dc.contributor.author |
Kirova, V |
|
| dc.contributor.author |
Masse-Chabredier, I |
|
| dc.contributor.author |
Oncu, S |
|
| dc.contributor.author |
Sener, A |
|
| dc.contributor.author |
Tekin, R |
|
| dc.contributor.author |
Deveci, O |
|
| dc.contributor.author |
Karabay, O |
|
| dc.contributor.author |
Agalar, C |
|
| dc.date.accessioned |
2022-10-13T12:31:44Z |
|
| dc.date.available |
2022-10-13T12:31:44Z |
|
| dc.date.issued |
2014 |
|
| dc.identifier.uri |
http://hdl.handle.net/11616/80159 |
|
| dc.description.abstract |
We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon- release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Lowenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p<0.05 for both). Accordingly, CSF L-J culture was superior to CSF-PCR (p<0.05). Combination of L-J and ACS was superior to using these tests alone (p<0.05). There were poor and inverse agreements between EZNs and L-J culture (=-0.189); ACS and L-J culture (=-0.172) (p<0.05 for both). Fair and inverse agreement was detected for CSF-ADA and CSF-PCR (=-0.299, p<0.05). Diagnostic accuracy of TBM was increased when both ACS and L-J cultures were used together. Non-culture tests contributed to TBM diagnosis to a degree. However, due to the delays in the diagnosis with any of the cultures, combined use of non-culture tests appears to contribute early diagnosis. Hence, the diagnostic approach to TBM should be individualized according to the technical capacities of medical institutions particularly in those with poor resources. |
|
| dc.description.abstract |
C1 [Erdem, H.; Oncul, O.] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey. |
|
| dc.description.abstract |
[Ozturk-Engin, D.; Inan, A.; Ceran, N.] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey. |
|
| dc.description.abstract |
[Elaldi, N.] Cumhuriyet Univ Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey. |
|
| dc.description.abstract |
[Gulsun, S.] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey. |
|
| dc.description.abstract |
[Sengoz, G.; Pehlivanoglu, F.] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey. |
|
| dc.description.abstract |
[Crisan, A.] Victor Babes Univ Med & Pharm, Dept Infect Dis, Timisoara, Romania. |
|
| dc.description.abstract |
[Johansen, I. S.] Odense Univ Hosp, Dept Infect Dis Q, DK-5000 Odense, Denmark. |
|
| dc.description.abstract |
[Nechifor, M.] Gr T Popa Univ Med & Pharm, Dept Pharmacol, Iasi, Romania. |
|
| dc.description.abstract |
[Al-Mahdawi, A.] Baghdad Teaching Hosp, Dept Neurol, Baghdad, Iraq. |
|
| dc.description.abstract |
[Civljak, R.] Univ Zagreb Sch Med, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Zagreb, Croatia. |
|
| dc.description.abstract |
[Ozguler, M.; Akbulut, A.] Firat Univ Sch Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey. |
|
| dc.description.abstract |
[Savic, B.] Univ Belgrade, Inst Microbiol & Immunol, Natl Reference Lab TB, Fac Med, Belgrade, Serbia. |
|
| dc.description.abstract |
[Cacopardo, B.] Univ Catania, Infect Dis Sect, Dept Clin & Mol Biomed, Catania, Italy. |
|
| dc.description.abstract |
[Inal, A. S.] Cukurova Univ Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey. |
|
| dc.description.abstract |
[Namiduru, M.] Gaziantep Univ Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey. |
|
| dc.description.abstract |
[Dayan, S.; Tekin, R.; Deveci, O.] Dicle Univ Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey. |
|
| dc.description.abstract |
[Kayabas, U.] Inonu Univ Sch Med, Dept Infect Dis & Clin Microbiol, Malatya, Turkey. |
|
| dc.description.abstract |
[Parlak, E.; Parlak, M.] Ataturk Univ Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey. |
|
| dc.description.abstract |
[Khalifa, A.] Damascus Hosp, Dept Neurol, Damascus, Syria. |
|
| dc.description.abstract |
[Kursun, E.] Baskent Univ Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey. |
|
| dc.description.abstract |
[Sipahi, O. R.] Ege Univ Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey. |
|
| dc.description.abstract |
[Yemisen, M.] Istanbul Univ Cerrahpasa Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey. |
|
| dc.description.abstract |
[Bitirgen, M.; Kandemir, B.] Necmettin Erbakan Univ Sch Med, Dept Infect Dis & Clin Microbiol, Konya, Turkey. |
|
| dc.description.abstract |
[Dulovic, O.] Univ Belgrade, Clin Infect & Trop Dis, Clin Ctr Serbia, Fac Med, Belgrade, Serbia. |
|
| dc.description.abstract |
[Luca, C.] Gr T Popa Univ Med & Pharm, Dept Infect Dis, Iasi, Romania. |
|
| dc.description.abstract |
[Stahl, J. P.] Joseph Fourier Univ & Univ Hosp Grenoble, Dept Infect Dis, Grenoble, France. |
|
| dc.description.abstract |
[Simeon, S.] Univ Hosp Pontchaillou, Dept Infect & Trop Dis, Rennes, France. |
|
| dc.description.abstract |
[Ulu-Kilic, A.; Alabay, S.] Erciyes Univ Sch Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey. |
|
| dc.description.abstract |
[Yasar, K.] Bakrkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey. |
|
| dc.description.abstract |
[Yilmaz, G.] Ankara Univ Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey. |
|
| dc.description.abstract |
[Yilmaz, E.] Uludag Univ Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey. |
|
| dc.description.abstract |
[Beovic, B.] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia. |
|
| dc.description.abstract |
[Catroux, M.] Univ Poitiers Hosp, Dept Infect Dis, Poitiers, France. |
|
| dc.description.abstract |
[Lakatos, B.] St Laszlo Hosp, Dept Infect Dis, Budapest, Hungary. |
|
| dc.description.abstract |
[Sunbul, M.] Ondokuz Mayis Univ Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey. |
|
| dc.description.abstract |
[Sahin-Horasan, E.] Mersin Univ Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey. |
|
| dc.description.abstract |
[Kose, S.] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey. |
|
| dc.description.abstract |
[Shehata, G.] Assiut Univ Hosp, Dept Neurol & Psychiat, Assiut, Egypt. |
|
| dc.description.abstract |
[Andre, K.] Dax Hosp, Dept Infect Dis, Dax, France. |
|
| dc.description.abstract |
[Alp, A.] Hacettepe Univ, Sch Med, Deparment Med Microbiol, Ankara, Turkey. |
|
| dc.description.abstract |
[Cosic, G.] Univ Novi Sad, Fac Med, Dept Prevent & Control Dis, IPH Vojvodina, Novi Sad, Serbia. |
|
| dc.description.abstract |
[Gul, H. Cem; Karakas, A.] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey. |
|
| dc.description.abstract |
[Chadapaud, S.] Marie Jose Treffot Hosp, Dept Infect Dis, Hyeres, France. |
|
| dc.description.abstract |
[Hansmann, Y.] Univ Hosp, Dept Infect Dis, Strasbourg, France. |
|
| dc.description.abstract |
[Harxhi, A.] Univ Hosp Ctr Tirana, Infect Dis Serv, Tirana, Albania. |
|
| dc.description.abstract |
[Kirova, V.] Univ Clin Infect Dis & Febrile Condit, Skopje, Macedonia. |
|
| dc.description.abstract |
[Masse-Chabredier, I.] Aurillac Hosp, Dept Infect Dis, Aurillac, France. |
|
| dc.description.abstract |
[Oncu, S.] Adnan Menderes Univ Sch Med, Dept Infect Dis & Clin Microbiol, Aydin, Turkey. |
|
| dc.description.abstract |
[Sener, A.] Onsekiz Mart Univ Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey. |
|
| dc.description.abstract |
[Karabay, O.] Sakarya Univ Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey. |
|
| dc.description.abstract |
[Agalar, C.] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey. |
|
| dc.source |
CLINICAL MICROBIOLOGY AND INFECTION |
|
| dc.title |
The microbiological diagnosis of tuberculous meningitis: results of |
|
| dc.title |
Haydarpasa-1 study |
|