Single-Center Analysis of the First 304 Living-Donor Liver

Abstract

Background/Aims: Living donor liver transplantations (LDLT) is a definitive treatment for patients with end-stage liver disease (ESLD), especially in the countries with donation problem. Between April 2007 and April 2010, we performed LDLT in 289 patients. Fifteen of the cases required re-transplantations. This study evaluates these 304 consecutive LDLTs donor and recipient outcomes. Methodology: Complication rates and survival data of the recipients and donors of 304 LDLT cases were analyzed. Results: All donors are alive and well. Overall complication rate was 27%. Early postoperative recipient complication rate was 51%. Most frequent complication was infection. In the long-term there were 57 biliary stricture and 5 chronic bile fistula cases. Chronic and acute rejection attacks developed in 7 and 103 patients, respectively. Hepatic artery thrombosis rate was 8%. One, two and three year survival rates were 82%, 79% and 75%, respectively. Recipient mortality was 25%, mostly due to vascular complications, septic complications, liver dysfunction and chronic rejection. Conclusions: More than 150 liver tranplantations per year in a single center is a challenge in Turkey, where there is a shortage of deceased donor grafts. LDLT is a safe procedure for donors and effective for ESLD. Improvement in surgical technique would provide better outcomes.

C1 [Yilmaz, Sezai; Kayaalp, Cuneyt; Ara, Cengiz; Yilmaz, Mehmet; Isik, Burak; Aydin, Cemalettin; Ozgor, Dincer; Dirican, Abuzer; Barut, Bora; Unal, Bulent; Piskin, Turgut; Ates, Mustafa; Kirimlioglu, Vedat] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Gen Surg, Malatya, Turkey.

[Yilmaz, Sezai; Kayaalp, Cuneyt; Ara, Cengiz; Yilmaz, Mehmet; Isik, Burak; Aydin, Cemalettin; Ozgor, Dincer; Dirican, Abuzer; Barut, Bora; Unal, Bulent; Piskin, Turgut; Ates, Mustafa; Kirimlioglu, Vedat] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Liver Transplantat Unit, Malatya, Turkey.

[Kutlu, Ramazan] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Radiol, Malatya, Turkey.

[Toprak, Huseyin Ilksen] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Anesthesiol, Malatya, Turkey.

[Bayindir, Yasar] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Infect Dis, Malatya, Turkey.

[Kirimlioglu, Hale] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Pathol, Malatya, Turkey.

[Aladag, Murat; Harputluoglu, Murat; Yalcin, Kendal] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Transplantat Hepatol, Malatya, Turkey.

[Selimoglu, Ayse; Karabiber, Hamza] Inonu Univ, Sch Med, Turgut Ozal Med Ctr, Dept Pediat Transplantat Hepatol, Malatya, Turkey.