DSpace Repository

The effect of caffeic acid phenethyl ester CAPE against cholestatic liver injury in rats

Show simple item record

dc.contributor.author Çoban, Sacid
dc.contributor.author Yıldız, Fahrettin
dc.contributor.author Alpaslan, Terzi
dc.contributor.author Al, Behcet
dc.contributor.author Özgör, Dinçer
dc.contributor.author Ara, Cengiz
dc.contributor.author Ara, Cengiz
dc.contributor.author Polat, Alaadin
dc.contributor.author Esrefoğlu, Mukaddes
dc.date.accessioned 2018-02-07T13:28:17Z
dc.date.available 2018-02-07T13:28:17Z
dc.date.issued 2010
dc.identifier.citation Çoban, S. A., Yıldız, F., Terzi, A., Al, B., Özgör, D., Ara, C., … Eşrefoğlu, M. (2010). The Effect Of Caffeic Acid Phenethyl Ester Cape Against Cholestatic Liver İnjury İn Rats . J Surg Res, 0–0. tr_TR
dc.identifier.uri https://ac.els-cdn.com/S0022480408006793/1-s2.0-S0022480408006793-main.pdf?_tid=a142829e-0c05-11e8-a6b1-00000aacb35f&acdnat=1518008076_147f990ee631a2d88b8f33b18348c03f
dc.identifier.uri http://hdl.handle.net/11616/8054
dc.description Journal of Surgical Research 159, 674–679 (2010) tr_TR
dc.description.abstract Objectives. Caffeic acid phenethyl ester (CAPE) has been subjected to considerable investigations that have revealed its antioxidant and anti-inflammatory activities in different conditions. But there is not a previous investigation about its effect on cholestatic liver injury. The aim of this study was to investigate the effect of CAPE in rat liver against cholestatic liver injury induced by bile duct ligation. Methods. Swiss-albino rats were recruited in the study as follows; Group 1 rats subjected to simple laparotomy known as the sham group; Group 2 rats subjected to bile duct ligation (BDL); Group 3 bile duct ligated rats treated with CAPE. The third group received CAPE (10 mmol/kg) intraperitoneally daily throughout 14 d. Results. Data showed a decrease in g glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase levels (ALT) of the CAPE treated rats, compared with BDL group (P < 0.001, P < 0.01, and P < 0.02, respectively). In the CAPE treated rats, tissue levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were significantly lower than that of the BDL group (P < 0.001). The levels of glutathione (GSH) in CAPE treated rats were significantly higher than that of BDL group (P < 0.001). In CAPE treated group, the levels of interleukin1alpha (IL-1a) and interleukin-6 (IL-6) were signifi- cantly lower than that of BDL group (P < 0.03, P < 0.02, respectively). Administration of CAPE in the rats with biliary obstruction resulted in inhibition of necro-inflammation. Conclusion. These results suggest that treatment of CAPE maintains antioxidant defenses, reduces oxidative liver injury, cytokine damage, and necroinflammation in bile duct ligated rats. Thus, CAPE seems to be a promising agent for the attenuation of cholestatic liver injury. 2010 Elsevier Inc. All rights reserved. tr_TR
dc.language.iso eng tr_TR
dc.publisher J Surg Res, 0–0. tr_TR
dc.rights info:eu-repo/semantics/openAccess tr_TR
dc.subject Caffeic acid phenethyl ester (CAPE) tr_TR
dc.subject Bile duct ligation tr_TR
dc.subject Cholestatic liver injury tr_TR
dc.title The effect of caffeic acid phenethyl ester CAPE against cholestatic liver injury in rats tr_TR
dc.type article tr_TR
dc.relation.journal J Surg Res, 0–0. tr_TR
dc.contributor.department İnönü Üniversitesi tr_TR
dc.identifier.volume 0 tr_TR
dc.identifier.issue 0 tr_TR
dc.identifier.startpage 0 tr_TR
dc.identifier.endpage 0 tr_TR

Files in this item

This item appears in the following Collection(s)

Show simple item record