The Humoral Immun Response of Mice to Liposomes Containing Brucella

Abstract

ORTUS RB51; BALB/C MICE; LIPOPOLYSACCHARIDE; MICROPARTICLES;

Brucellosis is an important zoonotic disease and the prevention is made by vaccination of animals. For ewes Brucella melitensis REV-I live attenuated vaccine is widely used but because of some risks such as being infected during the vaccination, re-infection of animals, a new vaccine with less side effect is need to be improved. In this Study it was aimed to determine a strong humoral immune response by encapsulating the Brucella outer membrane antigens with the optimum liposome formulation and the statistical analyses showed that the Brucella outer membrane extract encapsulated with liposome can evoke humoral immune response better than live attenuated B. melitensis REV-1 vaccine in mice.

C1 [Onurdag, Fatma Kaynak; Abbasoglu, Uflik] Gazi Univ, Fac Pharm, Dept Pharmaceut Microbiol, Ankara, Turkey.

[Degim, Tuncer; Degim, Zelihagul] Gazi Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey.

[Kutlu, Ismail] Antigen Antiserum Prod Lab, Ref Saydam Natl Hyg Ctr, Ankara, Turkey.

[Kaynar, Ozgur] Ataturk Univ, Fac Vet Med, Dept Biochem, Erzurum, Turkey.

[Gunes, Gulsen] Inonu Univ, Fac Med, Dept Publ Hlth, Malatya, Turkey.