The aim of this study is to evaluate the carbonhydrate metabolism in pregnants with abnormal glucose challenge, but normal 100g-3-hour oral glucose tolerance test. Pregnants who were delivered at Ynonu University School of Medicine Department of Obstetrics and Gynecology and meet the criteria included the study. Group 1(n:6) gestational diabetes mellitus, Group 2(n: 8) Type 2 diabetes mellitus, Group 3(n: 10) plasma glucose levels were 140mg/dl f after glucose challenge test, but normal 100g-oral glucose tolerance test, Group 4(n:8) pregnants with normal glucose challenge test and have appropriate-for-gestational-age neonate as control group,Group 5(n:8) pregnants with normal glucose challenge test and have macrosomic neonate were included the study. Maternal blood was collected to evaluate the carbonhydrate metabolism by comparing the IGF-I,II and IGFBP-1,2,3 levels. IGF I-II and IGFBP1,2,3 measurements were done by RIA and IRMA technics respectively. Maternal plasma levels of IGF-II and IGFBP-1, -3 were found to be significantly higher than control group in gestational diabetics, type-2 diabetic pregnants, pregnants with abnormal glucose challenge test but normal 100g-oral tolerance test and pregnants with macrosomic infant (p<0.000, p<0.000, p<0.05, p<0.05).
C1 Inonu Univ, Fac Med, Dept Obstet & Gynecol, Malatya, Turkey.