Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant and anti-inflammatory properties. To determine whether CAPE offers any advantage over alpha -tocopherol, we compared their effects on an in vivo model of renal ischemia-reperfusion injury in rats. CAFE at 10 mu mol/kg or alpha -tocopherol at 10 mg/kg was administered intraperitoneally before reperfusion. Acute administration of CAFE suppressed ischemia-reperfusion induced renal lipid peroxidation and tissue injury more than alpha -tocopherol. CAFE may therefore offer a therapeutic advantage in acute injury settings.
C1 Inonu Univ, Fac Med, Dept Pediat Surg, Malatya, Turkey.
Inonu Univ, Fac Med, Dept Biochem, Malatya, Turkey.
Inonu Univ, Fac Med, Dept Pediat, Malatya, Turkey.
Inonu Univ, Fac Med, Dept Histol & Embryol, Malatya, Turkey.