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Epidemiologic and clinical characteristics of neonates with late-onset

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dc.contributor.author Akin, IM
dc.contributor.author Kanburoglu, MK
dc.contributor.author Tayman, C
dc.contributor.author Oncel, MY
dc.contributor.author Imdadoglu, T
dc.contributor.author Dilek, M
dc.contributor.author Yaman, A
dc.contributor.author Narter, F
dc.contributor.author Er, I
dc.contributor.author Kahveci, H
dc.contributor.author Erdeve, O
dc.contributor.author Koc, E
dc.date.accessioned 2023-01-02T08:53:11Z
dc.date.available 2023-01-02T08:53:11Z
dc.date.issued 2022
dc.identifier.uri http://hdl.handle.net/11616/86981
dc.description.abstract The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17-21.71), tachypnea (OR: 26.5, 95% CI: 9.59-73.19), and chest retractions (OR: 27.5, 95% CI: 5.96-126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%.
dc.description.abstract Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course.
dc.source EUROPEAN JOURNAL OF PEDIATRICS
dc.title Epidemiologic and clinical characteristics of neonates with late-onset


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