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Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats

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dc.contributor.author Elbe, H.
dc.contributor.author Esrefoglu, M.
dc.contributor.author Vardi, N.
dc.contributor.author Taslidere, E.
dc.contributor.author Ozerol, E.
dc.contributor.author Tanbek, K.
dc.date.accessioned 2020-06-16T10:37:33Z
dc.date.available 2020-06-16T10:37:33Z
dc.date.issued 2015-09
dc.identifier.citation Elbe, H., Esrefoglu, M., Vardi, N., Taslidere, E., Ozerol, E., Tanbek, K. Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats. (2015). Human and Experimental Toxicology. tr_TR
dc.identifier.issn 09603271
dc.identifier.other DOI: 10.1177/0960327114559993
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/15787
dc.description Human and Experimental Toxicology Volume 34, Issue 9, 21 September 2015, Pages 859-868 tr_TR
dc.description.abstract In this study, effects of melatonin, quercetin and resveratrol on hepatocellular injury in streptozotocin (STZ)-induced experimental diabetes were aimed to be investigated by histological and biochemical methods. Thirty-five male Wistar albino rats were divided into five groups, namely, control, diabetes (STZ 45 mg/kg/single dose/intraperitoneally (ip)), diabetes + melatonin (10 mg/kg/30 days/ip), diabetes + quercetin (25 mg/kg/30 days/ip) and diabetes + resveratrol (10 mg/kg/30 days/ip). Initial and final blood glucose levels and body weights (BWs) were measured. At the end of the experimentation, following routine tissue processing procedure, sections were stained with haematoxylin-eosin (H-E), periodic acid Schiff and Massons trichrome. Tissue malondialdehyde (MDA) and glutathione (GSH) levels and superoxide dismutase (SOD) and catalase (CAT) activities were examined. The diabetic rats had significantly higher blood glucose levels than those of control rats (p = 0.0001). Mean BWs of diabetic rats were significantly decreased when compared with the control rats (p = 0.0013). Histopathological alterations including cellular glycogen depletion, congestion, sinusoidal dilatation, inflammation and fibrosis were detected in diabetes group. On the other hand, histopathological changes markedly reduced in all of the treatment groups (p = 0.001). Mean tissue MDA level was increased but mean tissue CAT and SOD activities and GSH levels were decreased in the diabetes group. Melatonin, quercetin and resveratrol administered diabetic rats showed an increase in CAT activities and GSH levels and a decrease in MDA levels (p < 0.05, for all). Melatonin, quercetin and resveratrol administrations markedly reduced hepatocellular injury in STZ-induced experimental diabetes. © SAGE Publications. tr_TR
dc.language.iso en tr_TR
dc.publisher SAGE PUBLICATIONS LTD tr_TR
dc.subject Optimization tr_TR
dc.subject Diabetic rats tr_TR
dc.subject Boolean functions tr_TR
dc.title Melatonin, quercetin and resveratrol attenuates oxidative hepatocellular injury in streptozotocin-induced diabetic rats tr_TR
dc.type Article tr_TR


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