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Protective and Therapeutic Effect of Apocynin on Bleomycin-Induced Lung Fibrosis in Rats

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dc.contributor.author Kilic, Talat
dc.contributor.author Parlakpinar, Hakan
dc.contributor.author Taslidere, Elif
dc.contributor.author Yildiz, Sedat
dc.contributor.author Polat, Alaadin
dc.contributor.author Vardi, Nigar
dc.contributor.author Colak, Cemil
dc.contributor.author Ermis, Hilal
dc.date.accessioned 2020-06-22T10:07:35Z
dc.date.available 2020-06-22T10:07:35Z
dc.date.issued 2015-06
dc.identifier.citation Kilic, T., Parlakpinar, H., Taslidere, E., Yildiz, S., Polat, A., Vardi, N., Colak, C., Ermis, H. Protective and Therapeutic Effect of Apocynin on Bleomycin-Induced Lung Fibrosis in Rats. (2015). INFLAMMATION. tr_TR
dc.identifier.issn 0360-3997
dc.identifier.issn 1573-2576
dc.identifier.other DOI: 10.1007/s10753-014-0081-1
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/15974
dc.description INFLAMMATION Volume: 38 Issue: 3 Pages: 1166-1180 tr_TR
dc.description.abstract We aimed to investigate the preventive and therapeutic effect of apocynin (APO) on bleomycin (BLC)-induced lung injury in rats. Rats were assigned into groups as follows: control group; APO group, 20 mg/kg APO was given intraperitoneal for 29 days; BLC-1 and BLC-2 groups, a single intratracheal injection of BLC (2.5 mg/kg); APO+BLC-preventive group, 20 mg/kg APO was administered 12 h before the intratracheal BLC injection and continued for 14 days; BLC+APO-treatment group, 20 mg/kg APO was given on the 14th day after the intratracheal BLC injection and continued to sacrifice. The BLC-1 group was sacrificed on the 14th day of BLC administration to validate BLC-induced lung inflammation and fibrosis on the 14th of study initiation. All other groups were sacrificed on the 29th day after BLC administration. The semiquantitative histopathological assessment, tissue levels of malondialdehyde (MDA), superoxide dismutase, catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant capacity, total oxidant status (TOS), and oxidative stress index (OSI) were measured. An addition to the serum myeloperoxidase (MPO), the cell count and cytokines (IL-1 beta, IL-6, and IL-8) of bronchoalveolar lavage (BAL) fluid were assayed. BLC-provoked histological changes were significantly detected compared to the control group. APO restored these histological damages in different quantity in the treatment and prevention groups. BLC caused a significant decrease in GSH, CAT, and GPX, which were accompanied with significantly the increased MDA, TOS levels, and OSI in the lung tissue concomitant with increased levels of the cellular account and proinflammatory cytokines in the BAL fluid. Otherwise, APO administration, both before and after BLC, reversed all biochemical markers and cytokine as well as histopathological changes induced by BLC. Interestingly, APO treatment reversed MPO activity in serum increased by BLC. In this study, both protective and therapeutic effects of APO against BLC-induced lung fibrosis were demonstrated for the first time. tr_TR
dc.description.sponsorship Inonu University -- 2013/112 tr_TR
dc.language.iso en tr_TR
dc.publisher SPRINGER/PLENUM PUBLISHERS, tr_TR
dc.subject bleomycin tr_TR
dc.subject apocynin tr_TR
dc.subject pulmonary fibrosis tr_TR
dc.subject antioxidant tr_TR
dc.subject cytokine tr_TR
dc.title Protective and Therapeutic Effect of Apocynin on Bleomycin-Induced Lung Fibrosis in Rats tr_TR
dc.type Article tr_TR


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