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Protective effect of sitagliptin against renal ischemia reperfusion injury in rats

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dc.contributor.author Nuransoy, Ayse
dc.contributor.author Beytur, Ali
dc.contributor.author Polat, Alaadin
dc.contributor.author Samdanci, Emine
dc.contributor.author Sagir, Mustafa
dc.contributor.author Parlakpinar, Hakan
dc.date.accessioned 2020-06-22T10:38:37Z
dc.date.available 2020-06-22T10:38:37Z
dc.date.issued 2015-05
dc.identifier.citation Nuransoy, A., Beytur, A., Polat, A., Samdanci, E., Sagir, M., Parlakpinar, H. Protective effect of sitagliptin against renal ischemia reperfusion injury in rats. (2015). RENAL FAILURE. tr_TR
dc.identifier.issn 0886-022X
dc.identifier.issn 1525-6049
dc.identifier.other DOI: 10.3109/0886022X.2015.1010991
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/15975
dc.description RENAL FAILURE Volume: 37 Issue: 4 Pages: 687-693 tr_TR
dc.description.abstract This study was designed to investigate the protective effects of sitagliptin on renal damage induced by renal ischemia reperfusion (I/R) in rats. For this, rats were randomly divided into four groups (n = 8): (1) sham group, in which the rats only underwent right nephrectomy; (2) right nephrectomy and left kidney ischemia (1 h) and reperfusion (24 h) group (I/R); (3) 5 mg/kg sitagliptin administrated group, per-oral once a day for two weeks; (4) 5 mg/kg sitagliptin administrated group, per-oral once a day for two weeks before left kidney I/R (n = 8). Sitagliptin-treated rats that underwent renal I/R demonstrated significant decrease in the serum urea nitrogen and creatinine and also, lipid peroxidation, total oxidant status and malondialdehyde level in the renal tissue when compared to the renal I/R group. Additionally, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and total antioxidative capacity were significantly increased after renal I/R in sitagliptin-treated rats. Our histopathological findings were in accordance with these biochemical results. In sum, in the current study all of our results indicated that sitagliptin treatment ameliorated renal damage induced by renal I/R in rats. tr_TR
dc.description.sponsorship Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) -- 2209/A-2012 tr_TR
dc.language.iso en tr_TR
dc.publisher TAYLOR & FRANCIS LTD tr_TR
dc.subject Ischemia-reperfusion injury tr_TR
dc.subject sitagliptin tr_TR
dc.subject oxidative stress tr_TR
dc.subject kidney tr_TR
dc.subject rat tr_TR
dc.title Protective effect of sitagliptin against renal ischemia reperfusion injury in rats tr_TR
dc.type Article tr_TR


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