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Synthesis, anticonvulsant and antimicrobial activities of some new [1-(2-naphthyl)-2-(pyrazol-1-yl)ethanone]oxime ethers

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dc.contributor.author Ozdemir, Zeynep
dc.contributor.author Karakurt, Arzu
dc.contributor.author Calis, Unsal
dc.contributor.author Gunal, Selami
dc.contributor.author Isik, Samil
dc.contributor.author Sahin, Z. Sibel
dc.contributor.author Dalkara, Sevim
dc.date.accessioned 2020-06-26T11:10:58Z
dc.date.available 2020-06-26T11:10:58Z
dc.date.issued 2015
dc.identifier.citation Ozdemir, Z., Karakurt, A., Calis, U., Gunal, S., Isik, S., Sahin, Z.S., Dalkara, S. Synthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethers. (2015). MEDICINAL CHEMISTRY. tr_TR
dc.identifier.issn 1573-4064
dc.identifier.issn 1875-6638
dc.identifier.uri http://localhost:8080/xmlui/handle/123456789/16096
dc.description MEDICINAL CHEMISTRY Volume: 11 Issue: 1 Pages: 41-49 Published: 2015 Document Type:Article tr_TR
dc.description.abstract In this study, 12 new oxime ether derivatives, which were expected to show anticonvulsant and antimicrobial activities, were synthesized. Oxime ether derivatives were synthesized by the reaction of various alkyl halides with 1-(2-naphthyl)- 2-(pyrazol-1-yl)ethanone oxime. Anticonvulsant activity of the compounds was determined by maximal electroshock (MES) and subcutaneous metrazol (ScM) seizure tests, while neurological disorders were evaluated using rotorod toxicity test according to the ASP of NIH. Compound 1, 6 and 7 showed anticonvulsant activity at 300 mg/kg dose at 4 h, but compounds 1 and 7 showed toxicity at 300 mg/kg dose at half an hour. Antimicrobial activities of the compounds were also determined using agar microdilution method. Compound 1 and 5 were found to have the highest antifungal activity among the other compounds. tr_TR
dc.description.sponsorship Inonu University -- 2009/25 tr_TR
dc.language.iso en tr_TR
dc.subject (Arylalkyl)azole tr_TR
dc.subject antimicrobial; X-ray crystallography tr_TR
dc.subject anticonvulsant tr_TR
dc.subject oxime ether tr_TR
dc.subject pyrazole tr_TR
dc.title Synthesis, anticonvulsant and antimicrobial activities of some new [1-(2-naphthyl)-2-(pyrazol-1-yl)ethanone]oxime ethers tr_TR
dc.type Article tr_TR

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