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Combined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized rats

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dc.contributor.author Tasdemir, S.
dc.contributor.author Tasdemir, C.
dc.contributor.author Vardi, N.
dc.contributor.author Parlakpinar, Hakan
dc.contributor.author Aglamis, E.
dc.contributor.author Ates, B.
dc.contributor.author Sagir, M.
dc.contributor.author Kurt, A.
dc.contributor.author Acet, A.
dc.date.accessioned 2020-07-10T11:19:32Z
dc.date.available 2020-07-10T11:19:32Z
dc.date.issued 2014
dc.identifier.citation Tasdemir, S., Tasdemir, C (Tasdemir, C., Vardi, N....[et all] Combined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized rats. (2014). BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY. tr_TR
dc.identifier.issn 0006-9248
dc.identifier.issn 1336-0345
dc.identifier.other DOI: 10.4149/BLL_2014_068
dc.identifier.uri http://abakus.inonu.edu.tr/xmlui/handle/123456789/16720
dc.description BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY Volume: 115 Issue: 6 Pages: 345-351 DOI: 10.4149/BLL_2014_068 Published: 2014 Document Type:Article tr_TR
dc.description.abstract Objective: The incidence of urinary bladder disturbances and renal structural changes and functional decline are found to increase with age. Methods: We investigated the effect of melatonin treatment in addition to estrogen replacement therapy in pine-alectomized (Px) and ovariectomized (Ovx) rats. 56 female Wistar rats were divided into seven groups, each containing eight animals: Sham, (Ovx), (Px), Px+Ovx, Px+Ovx receiving estrogen (Px+Ovx+E), Px+Ovx receiving melatonin (Px+Ovx+M) and Px+Ovx estrogen and melatonin supplemented (Px+Ovx+EM) group (EM group). We evaluated reduced glutathione (GSH) levels and malondialdehyde (MDA) levels. The mean collagen fiber (CF)/smooth muscle (SM) ratio in the bladder wall and structure of the kidney were examined histolologically. We aleso recorded response of the bladder contractility to acetylcholine (Ach). Results: Px and Ovx groups showed statistically significant reductions of antioxidant defenses, impaired Ach-evoked contraction, histological changes compared with the control group. Also, these changes were prominent in Px+Ovx group compared with all other groups. Both estrogen and melatonin reversed these changes however best restoration was observed in the EM group. Conclusions: Px performed in addition to Ovx led to a distinct increase in oxidative damage in bladder and renal tissue and deteriorate of the detrussor function. Either estradiol or melatonin replacement alone or in combination prevents significant alterations of tissue histology and bladder contractility following Ovx and Px. Thus, combination treatment appears to be the best method to restore both contractility and histomorphology of bladder and kidney tissues after Ovx and Px (Tab. 3, Fig. 4, Ref. 44). Text in PDF www.elis.sk. tr_TR
dc.description.sponsorship Inonu University tr_TR
dc.language.iso en tr_TR
dc.publisher COMENIUS UNIV tr_TR
dc.subject pinealectomy tr_TR
dc.subject ovariectomy tr_TR
dc.subject estrogen tr_TR
dc.subject melatonin tr_TR
dc.subject bladder tr_TR
dc.subject kidney tr_TR
dc.title Combined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized rats tr_TR
dc.type Article tr_TR


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