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Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats

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dc.contributor.author Şimşek, Yavuz
dc.contributor.author Parlakpınar, Hakan
dc.contributor.author Turhan, Uğur
dc.contributor.author Tağluk, Mehmet Emin
dc.contributor.author Ateş, Burhan
dc.date.accessioned 2020-07-15T09:50:36Z
dc.date.available 2020-07-15T09:50:36Z
dc.date.issued 2014
dc.identifier.citation Şimşek, Y., Parlakpinar, H., Turhan, U., Taǧluk, M.E., Ateş, B. Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats. (2014). Journal of the Turkish German Gynecology Association. tr_TR
dc.identifier.issn 13090399
dc.identifier.other DOI: 10.5152/jtgga.2014.26932
dc.identifier.uri http://abakus.inonu.edu.tr/xmlui/handle/123456789/16951
dc.description Journal of the Turkish German Gynecology Association Volume 15, Issue 2, 2014, Pages 86-91 tr_TR
dc.description.abstract Objective: In this experimental study, we aimed to investigate the role of melatonin on uterine myoelectrical activity of non-pregnant rats. Material and Methods: Forty-six female rats were assigned to six groups: (1) control; (0.2 mL 0.9% NaCl was injected intravenously (IV), n=6); (2) melatonin applied as 0.4 mg/kg/IV (n=8); (3) melatonin applied as 4 mg/kg/IV (n=8); (4) single dose of oxytocin (100 mU/kg) injected IV (n=8); (5) melatonin (0.4 mg/kg) plus oxytocin (100 mU/kg) (n=8); and (6) melatonin (4 mg/kg) plus oxytocin (100 mU/kg) injected IV (n=8). Each rat underwent a laparotomy, and uterine myoelectrical signals were recorded. The mean spectrum, averaged over the spectral content of signals in each group, was compared. Results: Melatonin induced uterine myoelectrical activity in a dose-dependent manner. Treatment of melatonin after oxytocin suppressed the mean power of the signals. Serum melatonin concentrations were significantly higher in melatonin-treated rats. Conclusion: Melatonin itself at two different dose levels was found to be equally effective in stimulating the uterine electrical signals, although oxytocin-induced uterine electrical activity was suppressed by melatonin. These findings merit further investigations on the possible beneficial role of melatonin in the treatment of conditions associated with abnormal uterine activity. © 2014 by the Turkish-German Gynecological Education and Research Foundation. tr_TR
dc.language.iso en tr_TR
dc.publisher AVES Ibrahim Kara tr_TR
dc.subject Electrical stimulation tr_TR
dc.subject Melatonin tr_TR
dc.subject Uterine contraction tr_TR
dc.title Dual effects of melatonin on uterine myoelectrical activity of non-pregnant rats tr_TR
dc.type Article tr_TR


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