Ulu, AhmetAygun, TugbaBirhanli, EmreAtes, Burhan2024-08-042024-08-0420220141-81301879-0003https://doi.org/10.1016/j.ijbiomac.2022.10.049https://hdl.handle.net/11616/100973Herein, we report a multifunctional hydrogel membrane with good mechanical properties, excellent antioxidant efficiency, and broad-spectrum antimicrobial activity. For this purpose, a series of chitosan-carboxymethyl cellulose-Pluronic P123 (CHT-CMC-P123) hydrogel membranes were prepared by blending various tetracycline hydrochloride (TCH) contents. The physicochemical and biological properties of CHT-CMC-P123 membranes were comprehensively investigated. With the increase of TCH content from 5 % to 20 %, hydrogel membranes presented a decreased water contact angle from 18.96 degrees to 11.24 degrees, and a decreased water vapor transmission rate from 171.8 to 156.1 g/m2 h. Besides, with the increase of TCH content (5-20 %), the tensile strength (0.31-0.11 MPa) and elongation at break (10.57-4.82 %) of hydrogel membranes decreased while their thickness increased (113.5-324.3 mu m). The data show that the release of TCH reached equilibrium after 26 days, with a cumulative percentage of approximately 28 %-87 %. Moreover, the hydrogel membranes exhibited a high antioxidant ca-pacity of-92 % for DPPH radical. Importantly, the incorporation of TCH significantly (-2.3 fold) enhanced the antimicrobial activity of the hydrogel membranes against Gram-positive, and Gram-negative bacteria and yeast. Based on our findings, these hydrogel membranes with superior properties may serve as effective food packaging and wound healing materials.eninfo:eu-repo/semantics/closedAccessChitosancarboxymethyl cellulosePluronicP123Hydrogel membraneTetracycline releaseAntioxidant and antimicrobial activityArticle222267026823622040210.1016/j.ijbiomac.2022.10.0492-s2.0-85141104810Q1WOS:000892275700003Q1