Demircan, MehmetGurunluoglu, KubilayBag, Harika Gozde GozukaraKocbiyik, AlperGul, MehmetUremis, NurayGul, Semir2024-08-042024-08-0420211306-696Xhttps://doi.org/10.14744/tjtes.2020.30483https://search.trdizin.gov.tr/yayin/detay/517003https://hdl.handle.net/11616/92579BACKGROUND: We aimed to evaluate the effects of two different burn dressings, hydrofiber with a silver (HFAg) and polylactic membrane (PLM), on altering the levels of important biomarkers Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-alpha), Transforming growth factor-beta(3) (TGF-beta(3)) in blood and burnt tissue in children with second-degree burns. METHODS: Children between the ages of one to 16 years, with 25-50% second-degree partial-thickness burns of the total body surface area were included in this study. Patients in the PLM group were dressed with PLM in a typical way according to the manual. The HFAg group was dressed with HFAg and a sterile cover. During and at the end of the 21-day treatment, blood and skin tissue samples were taken from the two burn and control groups. IL-6, TNF-alpha, and TGF-beta beta(3) levels were evaluated in blood and tissue samples from all groups, and the results were analyzed statistically. RESULTS: In the PLM group, IL-6 and TNF-alpha levels decreased early days in both serum and tissue samples to reach normal ranges compared with the HFAg group. In the PLM group, TGF-beta(3) levels were elevated than in other groups for two weeks. CONCLUSION: In this study, we found that PLM controls inflammation earlier in both systemic and burn tissue. We also found that PLM increased the level of TGF-beta(3), which may be associated with the prevention of the development of hypertrophic scar in the burn wound, in the blood and burn tissue during this study.eninfo:eu-repo/semantics/closedAccessBurnschildrendressingIL-6hydrofiber with silverpolylactic membraneTNF-alphaTGF-betaArticle2711221313339448510.14744/tjtes.2020.304832-s2.0-85099428890Q2517003WOS:000604992400021Q4