Aytac, S. PeriTozkoparan, BirsenKaynak, F. BetuelAktay, GoeknurGoektas, OezguerUenuevar, Songuel2024-08-042024-08-0420090223-52341768-3254https://doi.org/10.1016/j.ejmech.2009.06.026https://hdl.handle.net/11616/94886In this study, a new class of 4-amino-3-substituted-1,2,4-triazole-5-thiones (1-4) and their corresponding condensed derivatives 3,6-disubstituted 7H-1,2,4-triazolo[3,4-bi-1,3,4-thiadiazines (1a-4c) were synthesized and evaluated for their analgesic/anti-inflammatory activities. All synthesized compounds were also tested for their gastric toxicity and antioxidant activity on acute administration. Most of the compounds showed significant activity in both carrageenan-induced oedema and acetic acid-induced writhing tests besides negligible gastrointestinal toxicity. The compounds showing less ulcerogenic effect also showed less lipid peroxidation (LPO) level. Most promising results were obtained with the compounds that placed a fluoro or a chloride on the phenyl ring at the sixth position of the fused ring. (C) 2009 Elsevier Masson SAS. All rights reserved.eninfo:eu-repo/semantics/closedAccessAminomercaptotriazolesTriazolothiadiazinesAnalgesic/anti-inflammatory activityAntioxidant activityArticle4411452845381963274710.1016/j.ejmech.2009.06.0262-s2.0-70349777308Q1WOS:000271225800032Q1