Ozturk, Ebru OzerAslan, MehmetBayindir, Tuba2024-08-042024-08-0420220001-64891651-2251https://doi.org/10.1080/00016489.2022.2048072https://hdl.handle.net/11616/100547Background The impacts of coronavirus disease-2019 (COVID-19) on nasal mucociliary clearance (MCC) have shown conflicting results. Objectives The aim of this study was to determine whether COVID-19 infections affect nasal mucociliary activity using the saccharin test to measure nasal MCC time. Material and Methods This prospective comparative investigation included 25 patients with COVID-19 infection and 25 healthy controls. The nasal MCC time was assessed using the saccharin test. Saccharin test was applied to COVID-19 patients between the 10th and 20th days of COVID-19 test positivity. Patients admitted to the otolaryngology outpatient clinic with non-nasal symptoms and no history of COVID-19 infection served as the control subjects. Results Age, gender distribution, smoking, and alcohol usage, and the existence of other systemic disorders had no statistically significant differences between the groups (p = 0.25, p = 0.77, p = 1.00, p = 0.28, p = 0.54, respectively). The COVID-19 group had a mean nasal MCC time of 12.00 +/- 2.51 min, compared to 9.77 +/- 2.51 min in the control group. The nasal MCC time in the COVID-19 group was statistically significantly longer (p = 0.043). Conclusions and Significance The COVID-19 infection negatively affects mucociliary activity and causes prolongation of MCC. As the nasal defense mechanism weakens in the early period after COVID-19 infection, susceptibility to respiratory infections may occur.eninfo:eu-repo/semantics/closedAccessCOVID-19mucociliary clearancerespiratory infectionsaccharin testArticle1423-43293323529484110.1080/00016489.2022.20480722-s2.0-85126705833Q2WOS:000769867800001Q4