Baysal, TOzisik, HIKarlidag, RSarac, KBaysal, ODusak, AHazneci, E2024-08-042024-08-0420030028-39401432-1920https://doi.org/10.1007/s00234-003-1052-7https://hdl.handle.net/11616/93700Our aim was to investigate whether neurological impairment in Behcet's disease (BD) can be assessed by means of proton MRS and whether it can assist in prognosis. We used single-voxel MRS to measure metabolites in regions of normal-appearing pons, basal ganglia and periventricular white matter (PWM) in 32 patients with chronic BD patients with and without neurological deficits and 29 control subjects. Patients had significantly higher N-acetylaspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios in the basal ganglia than the controls. The Cho/Cr ratio in the PWM was also significantly higher in the patients. MRS enabled clear discrimination of patients and controls and also revealed spectral differences between non-neuro-Behcet's disease and neuro-Behcet's disease in the basal ganglia. MRS can be used to assess brain involvement in BD even if structural changes are absent.eninfo:eu-repo/semantics/closedAccessBehcet's diseasebrainmagnetic resonance spectroscopyArticle45128608641459344410.1007/s00234-003-1052-72-s2.0-0346025638Q1WOS:000186956400003Q2