Batcioglu, KOzturk, CKaragozler, AKaratas, F2024-08-042024-08-0420020263-64841099-0844https://doi.org/10.1002/cbf.958https://hdl.handle.net/11616/93377In this study, the relationship between selenium (Se) and glutathione peroxidase (GSHPx) levels was investigated in 7,12-dimethylbenz(a)anthracene (7,12-DMBA)-treated mouse liver. The potential mammary carcinogen 7,12-DMBA, was injected intraperitoneally (20 mg kg(-1) day(-1)) into 10-12 month old female mice. After 21 days of application the mice were sacrificed and GSHPx and Se levels of Liver homogenates were measured. Se and GSHPx levels in 7,12-DMBA-treated mice were significantly lower than those of controls (p<0.05). The control group exhibited 0.9 +/- 0.066 U mg(-1) protein and 0.86 +/- 0.058 p.p.m. levels of GSHPx and Se respectively. The 7,12-DMBA-treated group had significantly (p<0.05) decreased GSHPx and Se levels (0.42+/-0.062 U mg(-1) protein and 0.69+/-0.034 p.p.m. respectively). The results show a direct relationship between Se and GSHPx activity and a negative correlation between antioxidant capacity and existence of a carcinogen in metabolism. Copyright (C) 2001 John Wiley Sons, Ltd.eninfo:eu-repo/semantics/closedAccessSeGSH-Px7,12-DMBAArticle2021151181197950710.1002/cbf.9582-s2.0-0036096676Q2WOS:000175598700008Q4