Durgun, MustafaTurkes, CuneytIsik, MesutDemir, YelizSakli, AliKuru, AliGuzel, Abdussamat2024-08-042024-08-0420201475-63661475-6374https://doi.org/10.1080/14756366.2020.1746784https://hdl.handle.net/11616/99245Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, C-13 NMR, H-1 NMR, LC-MS and elemental analysis. Their inhibitory effect on AChE, and carbonic anhydrase I and II enzyme activities was investigated. Their antioxidant activity was determined using different bioanalytical assays such as radical scavenging tests with ABTS(center dot+), and DPPH center dot+ as well as metal-reducing abilities with CUPRAC, and FRAP assays. All compounds showed satisfactory enzyme inhibitory potency in nanomolar concentrations against AChE and CA isoforms with K-I values ranging from 10.14 +/- 0.03 to 100.58 +/- 1.90 nM. Amine group containing derivatives showed high metal reduction activity and about 70% ABTS radical scavenging activity. Due to their antioxidant activity and AChE inhibition, these novel compounds may be considered as leads for investigations in neurodegenerative diseases.eninfo:eu-repo/semantics/openAccessAcetylcholinesterasecarbonic anhydrasesynthesissulphonamidemolecular dockingArticle3519509623224970510.1080/14756366.2020.17467842-s2.0-85083022713Q1WOS:000523492900001Q1