Eşrefoğlu, MukaddesAkıncı, AyşinElbe, HülyaTaşlıdere, ElifTaşlıdere, ElifÇetin, AslıAteş, Burhan2020-10-212020-10-212014EŞREFOĞLU M,AKINCI A,ELBE H,TAŞLIDERE E,ÇETİN A,ATEŞ B (2014). Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats. Turkish Journal of Biology, 38(4), 493 - 501.1300-01521303-6092https://hdl.handle.net/11616/18454https://search.trdizin.gov.tr/yayin/detay/163049Abstract: In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even higher than those of control group in all of the organs. As a conclusion, we found melatonin very effective in reducing stress-induced organ damage by inhibiting lipid peroxidation and supporting the cellular antioxidant defense system.trinfo:eu-repo/semantics/openAccessArticle384493501163049WOS:000337274500008Q3