Gok, YetkinOzkan, GulKurucay, AliAtes, BurhanAktas, AydinDemirci, OzlemAygun, Muhittin2026-04-042026-04-0420260020-16931873-3255https://doi.org/10.1016/j.ica.2026.123062https://hdl.handle.net/11616/109602A series of morpholine(Morp.)-liganded palladium(II) complexes (1a-c) and triphenylphosphine(PPh3)-liganded palladium(II) complexes (2a-c) bearing 4-fluorobenzyl substituted N-heterocyclic carbene (NHC) were synthesized from NHC-Pd(II)-pyridine and Morp./PPh3 by ligand exchange method. The new complexes were fully characterized using 1H NMR, 13C NMR, 19F NMR, 31P NMR, FTIR spectroscopy and elemental analysis techniques. Furthermore, single crystal X-ray diffraction was used to elucidate the structures of complexes 1a and 2b. The anticancer activities of the new complexes against MCF-7 (Human Breast Cancer) cell line were investigated. With an IC50 value of 37.54 for complex 1a, it can be said that it is more cytotoxic to MCF-7 cells compared to other complexes, while the least cytotoxicity was observed in complex 1b.eninfo:eu-repo/semantics/closedAccessN -heterocyclic carbenesPalladiumAnticancer activityCrystal structureArticle59310.1016/j.ica.2026.1230622-s2.0-105026755672Q2WOS:001662421600001Q2