Karakas, SerdarYilmaz, SezaiInce, VolkanAkbulut, SamiDalda, YasinAkatli, Ayse NurKahraman, Aysegul Sagir2024-08-042024-08-0420231307-58882757-7392https://doi.org/10.14744/hf.2023.2023.0005https://search.trdizin.gov.tr/yayin/detay/1178884https://hdl.handle.net/11616/92730Background and Aim: Liver resection (LR) and liver transplantation (LT) are curative treatments for hepatocellular carcinoma (HCC). The main pur-pose of this study was to compare the survival of LR and LDLT in patients with HCC within the Milan criteria. Materials and Methods: The results of the LR (n=67) and LDLT (n=391) groups were compared for overall survival (OS) and disease-free survival (DFS). Twenty-six of the HCCs in the LRs met the Milan and Child A cri-teria. Also, 200 of the HCC patients in the LDLTs met the Milan criteria, of which 70 also met the Child A criteria. Results: Early mortality was higher in the LDLT group (13.9% vs 1.47%; p=0.003). The 5-year OS was higher in the LDLTs than the LRs, but not statistically significant (84.6% vs 74.2%; p=0.287). However, 5-year DFS was better in the LDLT group (96.8% vs 64.3%; p<0.001). When the LRs (n=26) and the LDLTs (n=70) that met both Milan and Child A criteria were compared, 5-year OS was similar (81.4% vs 74.2%; p=0.512), but DFS was better in the LDLTs (98.6% vs 64.3%; p<0.001). Conclusion: LR can be justified as the first-line treatment for HCC patients who meet Milan and Child A criteria in terms of and OS.eninfo:eu-repo/semantics/openAccessHepatocellular carcinomaliver resectionliver transplantationArticle4247523725092510.14744/hf.2023.2023.00052-s2.0-85164314245N/A1178884WOS:001000795000002Q4