Touj, NedraAl-Ayed, Abdullah S.Sauthier, MathieuMansour, LamjedHarrath, Abdel HalimAl-Tamimi, JamilOzdemir, Ismail2024-08-042024-08-0420182046-2069https://doi.org/10.1039/c8ra08897ghttps://hdl.handle.net/11616/98570N,N-Substituted benzimidazole salts were successfully synthesized and characterized by H-1-NMR, C-13 {H-1} NMR and IR techniques, which support the proposed structures. Catalysts generated in situ were efficiently used for the carbonylative cross-coupling reaction of 2 bromopyridine with various boronic acids. The reaction was carried out in THF at 110 degrees C in the presence of K2CO3 under inert conditions and yields unsymmetrical arylpyridine ketones. All N,N-substituted benzimidazole salts 2a-i and 4a-i studied in this work were screened for their cytotoxic activities against human cancer cell lines such us MDA-MB-231, MCF-7 and T47D. The N,N-substituted benzimidazoles 2e and 2f exhibited the most cytotoxic effect with promising cytotoxic activity with IC50 values of 4.45 g mL(-1) against MDA-MB-231 and 4.85 g mL(-1) against MCF7 respectively.eninfo:eu-repo/semantics/openAccessFriedel-Crafts AcylationComplexes SynthesisPyridine HalidesConvenient AccessGrignard-ReagentsMetal-ComplexesAryl HalidesLigandsDerivativesChloridesArticle87040000400153555824510.1039/c8ra08897g2-s2.0-85058245846Q2WOS:000452778800026Q2