Melekoglu, RaufCiftci, OsmanCetin, AshBasak, NeseCelik, Ebru2024-08-042024-08-0420160102-86501678-2674https://doi.org/10.1590/S0102-865020160080000009https://hdl.handle.net/11616/97496PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS: The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION: The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.eninfo:eu-repo/semantics/openAccessTetrachlorodibenzodioxinOxidative StressLeukotriene AntagonistsOvaryUterusArticle3185575632757988410.1590/S0102-8650201600800000092-s2.0-84985998580Q3WOS:000383883900009Q4