Celik, EbruCelik, OnderYilmaz, ErcanTurkcuoglu, IlginKaraer, AbdullahTurhan, UgurAydin, Suleyman2024-08-042024-08-0420130301-21151872-7654https://doi.org/10.1016/j.ejogrb.2012.10.032https://hdl.handle.net/11616/95970Objectives: To evaluate maternal and cord serum concentrations of salusin-alpha and salusin-beta in women with gestational diabetes mellitus (GDM) and with small-for-gestational age (SGA) fetuses. Study design: Pregnant women with GDM (n = 25), women with SGA (n = 20) and maternal age-matched normal healthy pregnant subjects (n = 25) participated in the study. Maternal serum and cord blood salusin-alpha and salusin-beta levels at the time of birth were measured using ELISA, and their relation with metabolic parameters was also assessed. Results: Mean concentrations of maternal and fetal serum salusin-alpha in the GDM and SGA groups were significantly lower than those of the controls (P < 0.001, P < 0.001, P < 0.001 and P < 0.001, respectively). Mean concentrations of maternal and cord blood salusin-beta also decreased in both the GDM and the SGA groups in comparison to the control group (P < 0.001, P < 0.001, P < 0.001 and P < 0.001, respectively). The concentrations of maternal serum salusin-alpha and salusin-beta were strongly positively correlated with the concentrations of cord blood salusin-alpha and salusin-beta (R = 0.92, P < 0.001 and R = 0.94, P < 0.001, respectively). Conclusions: The low levels of maternal serum salusin-alpha and salusin-beta may have negative impact on metabolic disorders and vascular dysfunction. (C) 2012 Elsevier Ireland Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessGestational diabetes mellitusSmall-for-gestational ageCord bloodSalusin-alphaSalusin-betaHOMA-IRArticle167129332317800410.1016/j.ejogrb.2012.10.0322-s2.0-84874512106N/AWOS:000316429200006Q3