Kustepe, Elif KayhanBahar, LeylaZayman, EmrahSucu, NehirGul, SemirGul, Mehmet2024-08-042024-08-0420201052-02951473-7760https://doi.org/10.1080/10520295.2019.1695942https://hdl.handle.net/11616/99274We investigated the effects of alpha-lipoic acid (AL) and alpha-tocopherol (AT) on renal histopathology in a streptozotocin (STZ) induced diabetic rat model. Adult male rats were divided into six groups: group 1, saline only; group 2, AL only; group 3, AT only; group 4, STZ only; group 5, STZ + AL; group 6 STZ + AT. Experimental diabetes was induced by STZ. AL and AT were administered for 15 days. Kidney sections were examined using a light microscope after hematoxylin and eosin (H & E), periodic acid-Schiff (PAS) and caspase-3 staining. Histological damage to glomeruli, tubule epithelial cells and basement membrane was observed in group 4. Administration of AT and AL reduced renal injury in the diabetic rats. Group 5 exhibited a greater curative effect on diabetic rats than group 6. AT and AL may be useful for preventing diabetic renal damage.eninfo:eu-repo/semantics/closedAccessalpha-lipoic acidalpha-tocopheroldiabeteskidneyratstreptozotocinArticle9543053163201359010.1080/10520295.2019.16959422-s2.0-85084380177Q2WOS:000512571700001Q4