Boztepe, CihangirKunkul, AsimGurbuz, NevinOzdemir, Ismail2024-08-042024-08-0420190538-80661097-4601https://doi.org/10.1002/kin.21321https://hdl.handle.net/11616/98978One of the most important challenges of the Suzuki reaction is a green synthesis of reaction products. In terms of economy and ecology, the Suzuki reaction details must be characterized for the industrial-scale Suzuki reaction processes. In this paper, for the first time, a kinetic and mechanistic study on the Suzuki reaction catalyzed with hydrogel-supported PEPPSI (pyridine-enhanced precatalyst preparation stabilization (and) initiation) type NHC-Pd-pyridine composite has been investigated. To determine the rate-limiting step, the effects of reactants and experimental conditions on the heterogeneous Suzuki reaction have been experimentally defined. The experimental results demonstrated that it is possible to reach 100% yield under the optimum reaction conditions, which were found as 75 x 10(-3) mol/L of phenylboronic acid (FBA), 50 x 10(-3) mol/L of bromoacetophenone (Brac), 125 x 10(-3) mol/L of K2CO3, 1 g/L of catalyst, 80 degrees C of reaction temperature, 400 rpm of mixing rate, and 3 h of reaction time. The transmetalation step in the cycle was defined as the rate-limiting step. On the basis of kinetic results, a mathematical reaction rate expression was presented assuming the steady-state approach to steps of the catalytic cycle. The activation energy (E-a) of the reaction was estimated to be 34.88 kJ/mol.eninfo:eu-repo/semantics/closedAccessheterogeneous catalystsreaction kineticsreaction mechanismsSuzuki reactionsArticle511293194210.1002/kin.213212-s2.0-85073463004Q3WOS:000487418900001Q4