Bayindir, TubaToplu, YukselOtlu, BarisYakupogullari, YusufYildirim, OzgeKalcioglu, Mahmut Tayyar2024-08-042024-08-0420151808-86941808-8686https://doi.org/10.1016/j.bjorl.2014.08.018https://hdl.handle.net/11616/96793Introduction: There is an ongoing debate about the existence and effects of Helicobacter pylori (Hp) in adenotonsillar tissue. Objective: A clinical study was conducted to assess the existence of Hp in the adenoid and/or adenotonsillar tissues, which were surgically excised due to chronic adenotonsillitis. Methods: Phosphoglucosamine mutase gene for the detection of Hp and cytotoxin-associated gene as virulence gene were examined in 84 adenotonsillar tissues obtained from 64 patients and patients' serum by using polymerase chain reaction. Results: Hp IgG was detected in 57 (89%) patients' serum. A total of seven tissue samples from 64 patients (10.9%) were found positive for Hp DNA, of which five were adenoids and two were tonsil tissues. All polymerase chain reaction positive samples were also positive for the cytotoxin-associated gene, which is a virulence determinant for the organism. Conclusion: This study suggests that children are exposed to Hp at an early age of their life in this province. Hp may have a role in the pathogenesis of chronic adenotonsillitis, especially in endemic areas. (C) 2015 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. All rights reserved.eninfo:eu-repo/semantics/openAccessHelicobacter pyloriReservoirsAdenoidsPalatine tonsilArticle8133073112590071910.1016/j.bjorl.2014.08.0182-s2.0-84929956230Q2WOS:000356908500014Q4