Toy, Vesile ElifAtaoglu, TamerEltas, AbubekirOtlu, Husniye GulKarabulut, Aysun Bay2024-08-042024-08-0420231432-69811436-3771https://doi.org/10.1007/s00784-022-04854-7https://hdl.handle.net/11616/101097Objectives Adipocytokines and oxidative stress (OS) are involved in the pathogenesis of both obesity and periodontitis. The aim of this study was to evaluate periodontal therapy outcomes in terms of serum and gingival crevicular fluid (GCF) levels of adipocytokines and OS markers in obese patients with periodontitis, in order to have an insight into the association between obesity and periodontitis.Materials and methods A total of 39 patients (20 obese, 19 non-obese) with periodontitis were included in this study. Clinical periodontal parameters were assessed; serum and GCF levels of adipocytokines and OS markers were evaluated by ELISA at baseline and 3 months after non-surgical periodontal therapy.Results Significant improvements in clinical periodontal parameters were observed in both groups at 3 months (p < 0.01). While serum levels of TNF-alpha, leptin, and total oxidant status (TOS) in the obese group were higher at baseline (p < 0.01), leptin levels remained higher at 3 months despite a significant decrease (p < 0.01). Although NSPT improved GCF levels of total antioxidant status (TAS) and TOS in both groups, they were significantly different between the groups after therapy (p < 0.05).Conclusions It seems that leptin, TNF-alpha, and TOS contribute to systemic inflammatory and oxidative state in patients with obesity. Despite improvements in clinical periodontal parameters, obesity might be a modulating factor in the development and progression of periodontal disease in terms of some adipocytokines and OS markers.eninfo:eu-repo/semantics/openAccessAdipocytokineNon-surgical periodontal therapyObesityOxidative stressArticle276276327733660434210.1007/s00784-022-04854-72-s2.0-85145674647Q1WOS:000909185400002Q1