Aktas, AydinCelepci, DuyguGok, YetkinTaslimi, ParhamAkincioglu, HulyaGulcin, Ilhami2024-08-042024-08-0420202073-4352https://doi.org/10.3390/cryst10030171https://hdl.handle.net/11616/99215In this study, a novel silver N-heterocyclic carbene (Ag-NHC) complex bearing hydroxyethyl substituent has been synthesized from the hydroxyethyl-substituted benzimidazolium salt and silver oxide by using in-situ deprotonation method. A structure of the Ag-NHC complex was characterized by using UV-Vis, FTIR, H-1-NMR and C-13-NMR spectroscopies and elemental analysis techniques. Also, the crystal structure of the novel complex was determined by single-crystal X-ray diffraction method. In this paper, compound 1 showed excellent inhibitory effects against some metabolic enzymes. This complex had Ki of 1.14 0.26 mu M against human carbonic anhydrase I (hCA I), 1.88 +/- 0.20 mu M against human carbonic anhydrase II (hCA I), and 10.75 +/- 2.47 mu M against alpha-glycosidase, respectively. On the other hand, the Ki value was found as 25.32 +/- 3.76 mu M against acetylcholinesterase (AChE) and 41.31 +/- 7.42 mu M against butyrylcholinesterase (BChE), respectively. These results showed that the complex had drug potency against some diseases related to using metabolic enzymes.eninfo:eu-repo/semantics/openAccessN-heterocyclic carbenecrystal structureenzyme inhibitioncarbonic anhydrasealpha-glycosidaseArticle10310.3390/cryst100301712-s2.0-85081269624Q2WOS:000523512100093Q2